{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:18:42Z","timestamp":1790954322357,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot complications that lead to lower extremity amputations pose a significant challenge to the entire global health system. In this multicentre clinical trial, 26 patients with chronic Wagner one diabetic foot ulcers (DFUs) were treated with a unique human keratin matrix graft applied either weekly or bi\u2010weekly, in addition to standard of care. The hypothesis was that bi\u2010weekly application would be similar to weekly application. The primary endpoint was complete wound closure by 12\u2009weeks, and secondary endpoints included healing time, percent area reduction and weekly changes in peripheral neuropathy, pain and quality of life. In the intent\u2010to\u2010treat population, 77% (10\/13) of DFUs treated with bi\u2010weekly application healed compared with 69% (9\/13) treated with weekly application. The mean time to heal within 12\u2009weeks in the bi\u2010weekly group was 61\u2009days and in the weekly group was 54\u2009days. The mean percent area reduction at 12\u2009weeks was 94.7% in the bi\u2010weekly group compared with 84.8% in the weekly group. The number of grafts used in the bi\u2010weekly group was 3.9 compared with 6.2 in the weekly group. The results of this trial confirm our hypothesis that whether bi\u2010weekly or weekly application of the unique keratin matrix graft is used to treat nonhealing indolent DFUs, there is a high rate of complete healing. Based on these results, future studies should be conducted that further investigate the use of this novel human keratin matrix graft for the treatment of chronic DFUs.<\/jats:p>","DOI":"10.1111\/iwj.70029","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T03:35:22Z","timestamp":1725852922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A multicentre clinical trial evaluating the outcomes of two application regimens of a unique keratin\u2010based graft in the treatment of Wagner grade one non\u2010healing diabetic foot ulcers"],"prefix":"10.1111","volume":"21","author":[{"given":"David G.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Division of Surgery, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute (PERI)  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Glat","sequence":"additional","affiliation":[{"name":"Department of Surgery Drexel University School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-6639","authenticated-orcid":false,"given":"Marissa J.","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  Bozeman Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hanft","sequence":"additional","affiliation":[{"name":"Doctors Research Network  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Surprenant","sequence":"additional","affiliation":[{"name":"Doctors Research Network  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5338-3445","authenticated-orcid":false,"given":"Adam L.","family":"Isaac","sequence":"additional","affiliation":[{"name":"Foot and Ankle Specialists of the Mid\u2010Atlantic (FASMA)  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M.","family":"Zelen","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute (PERI)  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1614"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2015.11.025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.06.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00383-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.5.692"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2023.2232256"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01505.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.04.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1295-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13137"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.58.10.3271-3275.1992"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13715"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002371"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12954"},{"issue":"12","key":"e_1_2_10_19_1","first-page":"711","article-title":"The management of diabetic foot ulcers with porcine small intestine sub\u2010mucosa tri\u2010layer matrix: a randomized controlled trial","volume":"4","author":"Cazzell SM","year":"2015","journal-title":"AdvWound Care"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12600"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12566"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12357"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12329"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:53:18Z","timestamp":1730789598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/iwj.70029"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70029","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70029"}}