{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:04:48Z","timestamp":1791821088974,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Our meta\u2010analysis aimed to quantify the association between Hidradenitis suppurativa (HS) and several risk factors including obesity, smoking, and type 2 diabetes mellitus (T2DM). We searched PubMed, Scopus, Embase, Web of Science, and cumulative index to nursing and allied health literature for articles reporting either the odds ratio (OR) or the numbers of HS cases associated with obesity, smoking, or T2DM, and including HS negative controls. Risk of bias was assessed against the risk of bias in non\u2010randomized studies of interventions tool. Data synthesis was done using the random effects model with heterogeneity being evaluated with\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    statistic. Twenty\u2010three studies with a total of 29\u2009562\u2009087 patients (average age of 36.6\u2009years) were included. Ten studies relied on country\u2010level data, while six studies collected their data from HS clinics. The analysis showed a significant association between HS and female sex (OR 2.34, 95% CI 1.89\u20132.90,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200998.6%), DM (OR 2.78, 95% CI 2.23\u20133.47,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200998.9%), obesity (OR 2.48, 95% CI 1.64\u20133.74,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200999.9%), and smoking (OR 3.10 95% CI 2.60\u20133.69,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200997.1%). Our meta\u2010analysis highlights HS links to sex, DM, obesity, and smoking, with emphasis on holistic management approach. Further research is needed on molecular mechanisms and additional risk factors for improved patient care.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70035","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T01:39:50Z","timestamp":1726191590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6009-3339","authenticated-orcid":false,"given":"Khaled E.","family":"Elzawawi","sequence":"first","affiliation":[{"name":"College of Medicine, QU Health Qatar University  Doha Qatar"},{"name":"Department of Medical Education Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Elmakaty","sequence":"additional","affiliation":[{"name":"Department of Medical Education Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Habibullah","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health Qatar University  Doha Qatar"},{"name":"Department of Medical Education Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Badie","family":"Ahmed","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health Qatar University  Doha Qatar"},{"name":"Department of Medical Education Hamad Medical Corporation (HMC)  Doha Qatar"},{"name":"Plastic Surgery Department, Hamad General Hospital Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Al Lahham","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Hamad General Hospital Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Al Harami","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Hamad General Hospital Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Albasti","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Hamad General Hospital Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Alsherawi","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Hamad General Hospital Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"BallardK ShumanVL.Hidradenitis Suppurativa. 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