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Four hundred forty\u2010six patients that were admitted to the hospital with moderate or severe foot infections were retrospectively reviewed. Tissue and bone cultures were obtained from the index hospital admission. Conversion was defined as methicillin susceptible <jats:italic>Staphylococcus aureus<\/jats:italic> in the first culture and subsequently MRSA when there was a reinfection. The incidence of MRSA was 7.8% (<jats:italic>n<\/jats:italic>\u2009=\u200935), with no significant difference between soft tissue infections (7.7%) and osteomyelitis (8.0%). MRSA incidence was 9.4 times higher in non\u2010diabetics (23.8% vs. 3.2%, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;0.01). The incidence of reinfection was 40.8% (<jats:italic>n<\/jats:italic>\u2009=\u2009182). Conversion to MRSA was seen in 2.2% (<jats:italic>n<\/jats:italic>\u2009=\u20094) total, occurring in 5.4%. Non\u2010diabetics were 20.1 times more likely to have MRSA reinfection than people with diabetes (28.6% vs. 1.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). MRSA patients had a higher proportion of healed wounds (82.4% vs. 69.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). There were no differences in other clinical outcomes in MRSA vs. other infections in reinfection (28.6% vs. 24.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.11), amputation (48.6% vs. 52.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.69) or hospitalization (28.6% vs. 42.6, <jats:italic>p<\/jats:italic>\u2009=\u20090.11). The incidence of MRSA for the first infection (7.8%), reinfection (6.0%) and conversion to MRSA (2.2%) was low. MRSA was 9.4 times more common in people without diabetes.<\/jats:p>","DOI":"10.1111\/iwj.70039","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T13:50:25Z","timestamp":1726235425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Methicillin\u2010resistant <i>Staphylococcus aureus<\/i> in diabetic and non\u2010diabetic foot infections"],"prefix":"10.1111","volume":"21","author":[{"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9516-3762","authenticated-orcid":false,"given":"Mario 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