{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:17:03Z","timestamp":1785377823837,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skin scarring can result from burns, injuries, stretch marks and acne, leading to cosmetic and functional difficulties. Treatments for burn scars encompass a range of options, such as lasers, corticosteroid injections, surgery and regenerative techniques such as platelet\u2010rich plasma (PRP). Hyaluronic acid\u2010based products offer skin hydration and shield against aging effects. A study is being conducted to evaluate how effective PRP injection, hyaluronic acid and their combination improve burn scars and their effects on quality of life and potential disabilities. In our study, PRP and non\u2010cross\u2010linked hyaluronic acid treatments were compared in 10 individuals with burn scars between 2022 and 2023. Patients received CO<jats:sub>2<\/jats:sub> fractional laser treatment followed by injections in scar areas. Evaluations included the Vancouver scar scale (VSS), biometric assessments, ultrasounds and satisfaction ratings. Two therapy sessions were conducted at 1\u2010month interval, and assessments were done before treatment, 1\u2009month after the first session, and 3\u2009months after the first session. Biometric assessments showed significant improvements in various parameters (tewametry, corneometry, erythema index, melanin index, cutometry, thickness and density) in the intervention groups compared to the placebo group (<jats:italic>p<\/jats:italic> &lt;0.05). PRP\u2010non\u2010cross\u2010linked hyaluronic acid, PRP and non\u2010cross\u2010linked hyaluronic acid treatments exhibited the best clinical responses with significant differences between groups (<jats:italic>p<\/jats:italic> &lt;0.05). Dermal thickness did not show significant improvement during treatment sessions, and changes among subjects were not significantly different. The colorimetry parameter improved in all groups except the placebo group, with no significant difference between intervention groups. The VSS significantly decreased in all treatment groups except the placebo group. PRP, non\u2010cross\u2010linked hyaluronic acid and especially the combination of these two treatment options are very effective in treating burn scars.<\/jats:p>","DOI":"10.1111\/iwj.70065","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T05:20:56Z","timestamp":1727932856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evaluation of the efficacy, safety and satisfaction rates of platelet\u2010rich plasma, non\u2010cross\u2010linked hyaluronic acid and the combination of platelet\u2010rich plasma and non\u2010cross\u2010linked hyaluronic acid in patients with burn scars treated with fractional <scp>CO<sub>2<\/sub><\/scp> laser: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Masoumeh","family":"Roohaninasab","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"},{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5878-9778","authenticated-orcid":false,"given":"Alireza","family":"Jafarzadeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"},{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Sadeghzadeh\u2010Bazargan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"},{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Zare","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Laser Application in Medical Sciences Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Stem Cell and Regenerative Medicine Institute Sharif University of Technology  Tehran Iran"},{"name":"Department of Mechanical Engineering Sharif University of Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nouri","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-8039","authenticated-orcid":false,"given":"Mohammad Ali","family":"Nilforoushzadeh","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Skin Repair Research Center Jordan Dermatology and Hair Transplantation Center  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-3460","authenticated-orcid":false,"given":"Elham","family":"Behrangi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"},{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03480-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00672"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14557"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-03976-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31829b334e"},{"issue":"5","key":"e_1_2_11_7_1","first-page":"1","article-title":"Platelet\u2010rich plasma (PRP): current applications in dermatology","volume":"24","author":"Emer J","year":"2019","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2059513118808773"},{"issue":"11","key":"e_1_2_11_9_1","first-page":"44","article-title":"Platelet\u2010rich plasma: a comprehensive review of emerging applications in medical and aesthetic dermatology","volume":"14","author":"White C","year":"2021","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_269_21"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels7010015"},{"issue":"6","key":"e_1_2_11_12_1","first-page":"441","article-title":"Hyaluronic acid in dermatology","volume":"15","author":"Keen MA","year":"2017","journal-title":"Skinmed"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000548"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000749732.09228.a9"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"6","article-title":"Evaluation of the effect of platelet\u2010rich plasma on post\u2010burn scars","volume":"5","author":"Elsayed M","year":"2017","journal-title":"J 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