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A post hoc analysis of 280 patients using pooled patient level data from three RTCs. Blood cultures were drawn at time of admission for DFI. Deep intraoperative cultures were obtained from infected foot wounds. Data from the 12\u2010month follow\u2010up were used to determine clinical outcomes. 77.1% (<jats:italic>N<\/jats:italic>\u2009=\u2009216) had blood cultures of which 15.7% (<jats:italic>n<\/jats:italic>\u2009=\u200934) had BSI. One patient (3.3%) had endocarditis. Risk factors for BSI included Charcot Neuroarthropathy history (20.6% vs. 7.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), low systolic blood pressure (128.3\u2009\u00b1\u200921.0 vs. 140.8\u2009\u00b1\u200922.2 <jats:italic>p<\/jats:italic>\u2009=\u20090.003), low diastolic blood pressure (71.6\u2009\u00b1\u20099.4 vs. 79.3\u2009\u00b1\u200911.5 <jats:italic>p<\/jats:italic> &lt;0.001), leucocytosis &gt;12 000 (55.9% vs. 29.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and elevated C\u2010reactive protein (CRP) (26.8\u2009\u00b1\u200931.2 vs. 12.0\u2009\u00b1\u200919.6, <jats:italic>p<\/jats:italic> &lt;0.001). During the index hospitalization, BSI patients had longer median hospitalizations (14.0, 11.3\u201318.0 vs. 12.0, 9.0\u201316.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). At 12\u2010months, BSI patients were more likely to be admitted to the hospital (all cause hospital admissions 35.3% vs. 18.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). There was no difference in re\u2010infection (20.6% vs. 32.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.21), foot\u2010specific hospitalizations (17.6% vs. 22.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.65), wounds healing (64.7% vs. 67.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.88), time to heal (221.0, 74.0\u2013365 vs. 109.5, 46.8\u2013365, <jats:italic>p<\/jats:italic>\u2009=\u20090.16) or antibiotic duration (46.0, 39.3\u201376.5 vs. 45.0, 22.3\u201367.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.09). The most common BSI pathogens were <jats:italic>Staphylococcus aureus<\/jats:italic> (79.4%) and <jats:italic>Streptococcus<\/jats:italic> spp. (50.0%) species. BSI is common in DFIs. Patients have longer hospitalizations and were more likely to be hospitalized after their initial discharge.<\/jats:p>","DOI":"10.1111\/iwj.70102","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:19:59Z","timestamp":1746418799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The infected diabetic foot: Bacteraemia and endocarditis complicating moderate and severe foot infections"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9516-3762","authenticated-orcid":false,"given":"Mario C.","family":"Reyes","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur N.","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Sideman","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Siah","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar J. 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