{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:06:58Z","timestamp":1780582018914,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19647"],"award-info":[{"award-number":["22K19647"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A wide variety of microbial species, including <jats:italic>Trichophyton<\/jats:italic> spp., have been detected in diabetic foot ulcers (DFUs). In particular, <jats:italic>Trichophyton<\/jats:italic> spp. cause tinea pedis (i.e., athlete's foot) and onychomycosis. However, investigations regarding the correlation between <jats:italic>Trichophyton<\/jats:italic> spp. and delayed wound healing are limited to case reports. Moreover, histological changes in wounds caused by <jats:italic>Trichophyton<\/jats:italic> spp. remain unclear. In this study, we sought to confirm the delayed wound healing phenotype caused by <jats:italic>Trichophyton mentagrophytes<\/jats:italic> infection in a full\u2010thickness excisional wound <jats:italic>ob\/ob<\/jats:italic> mouse model through histopathological analysis. The inoculation of skin wounds in <jats:italic>ob\/ob<\/jats:italic> mice with <jats:italic>T. mentagrophytes<\/jats:italic> sporules resulted in significant delay on wound healing. Further histopathological analyses demonstrated that the delayed wound healing in <jats:italic>ob\/ob<\/jats:italic> mice was accompanied by reduced collagen fibre formation and inhibited granulation tissue formation, with spores and elongated mycelia retained in the wound bed and along the wound edges. This suggests that <jats:italic>T. mentagrophytes<\/jats:italic> colonization of wounds potentially contributes to delayed wound healing in patients with diabetes. These results suggest that neglected tinea pedis is a potential risk factor for delayed wound healing and progression to refractory wounds in patients with DFU.<\/jats:p>","DOI":"10.1111\/iwj.70118","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T01:10:26Z","timestamp":1734311426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Trichophyton mentagrophytes<\/i> delays wound healing in <i>ob\/ob<\/i> mice"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1888-3070","authenticated-orcid":false,"given":"Kohsuke","family":"Aruga","sequence":"first","affiliation":[{"name":"Biofunctional Sciences, Department of Integrated Health Sciences Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"},{"name":"Fundamental Nursing, Department of Health Sciences Fujita Health University Graduate School of Health Science  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimie","family":"Takehara","sequence":"additional","affiliation":[{"name":"Fundamental Nursing, Department of Health Sciences Fujita Health University Graduate School of Health Science  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-6426","authenticated-orcid":false,"given":"Satoshi","family":"Kametaka","sequence":"additional","affiliation":[{"name":"Biofunctional Sciences, Department of Integrated Health Sciences Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"IDF Diabetes Atlas","author":"Magliano DJ","year":"2021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1614"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-018-0261-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1628-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130112.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.7.1627"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2016-000336"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0570-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-2131"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000891864.37619.34"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2022.07.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14895"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-43"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00501-08"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2321-3868.113329"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01035-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02035-09"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2011.20.1.40"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.110376"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"891","article-title":"Tinea pedis and onychomycosis frequency in diabetes mellitus patients and diabetic foot ulcers. 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