{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:53:38Z","timestamp":1787165618040,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To investigate risk factors for re\u2010infection and compare the outcomes in people with diabetic foot infections. A retrospective chart review was conducted, and 294 hospitalised patients with moderate to severe diabetic foot infections (DFIs) were analysed for this study. The diagnosis and classification of the severity of infection was based on the International Working Group on the Diabetic Foot (IWGDF) infection guidelines. Skin and soft tissue infections were diagnosed based on clinical observations as per IWGDF classification in addition to ruling out any suspected osteomyelitis (OM) through negative bone culture, MRI or WBC SPECT CT. OM was confirmed by bone culture or histopathology. Clinical outcomes were based on a 12\u2010month follow\u2010up period. All dichotomous outcomes were compared using\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    with an alpha of 0.05. The result of this study shows a 48% rate of re\u2010infection in people admitted to our hospital with moderate and severe diabetic foot infections (DFI). Patients with osteomyelitis present during the index admission were 2.1 times more likely to experience a re\u2010infection than patients with soft tissue infection (56.7% vs. 38.0% respectively). In the univariate analysis, risk factors for re\u2010infection included osteomyelitis, non\u2010healing wounds, prolonged wound healing, antidepressants and leukocytosis. In the regression analysis, the only risk factor for re\u2010infection was wounds that were not healed &gt;90\u2009days (HR =2.0, CI: 1.5, 2.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Re\u2010infection is very common in patients with moderate and severe diabetic foot infections. Risk factors include osteomyelitis, non\u2010healing wound, prolonged wound healing, antidepressants and leukocytosis.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70123","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T21:23:22Z","timestamp":1732137802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Re\u2010infection after treatment for moderate and severe diabetic foot infections"],"prefix":"10.1111","volume":"21","author":[{"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-6283","authenticated-orcid":false,"given":"Arthur N.","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Easton C.","family":"Ryan","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical School  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Crisologo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-8841","authenticated-orcid":false,"given":"Matthew","family":"Malone","sequence":"additional","affiliation":[{"name":"School of Medicine, Infectious Diseases and Microbiology, Western Sydney University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet A.","family":"Suludere","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee C.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane K.","family":"Wukich","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Southwestern Medical Center  Dallas Texas 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