{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:47:38Z","timestamp":1787168858402,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic foot wounds (DFW) are notoriously difficult to treat owing to poor vascularity, delayed healing and higher rates of infection. Human\u2010derived acellular dermal matrices (ADM) have been used in DFW treatment, utilizing a matrix scaffold for new tissue generation. We investigate the efficacy of a micronized injectable human\u2010derived ADM in the treatment of DFW. We retrospectively recruited 13 patients with diabetic foot wounds. Wounds were adequately debrided, and a micronized injectable ADM was applied. Wound sizes were recorded prior to treatment, at 2 and 4\u2009weeks post\u2010treatment. The mean defect of wounds treated was 19.21\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    . Our results showed a statistically significant reduction in wound size of 45% and 59% at 2 and 4\u2009weeks post\u2010treatment, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). ADM was also effective in infected DFW as 84% of our wounds had positive tissue cultures at the time of application. Micronized injectable ADM has proven to be an effective treatment for DFW. Advantages include a ready\u2010to\u2010use injectable, single\u2010stage treatment, minimal pain, mouldable matrix to fit any wound shape, allows for outpatient treatment and simple wound dressings.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70127","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T20:01:52Z","timestamp":1736712112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early experience on injectable micronized putty type human\u2010derived acellular dermal matrix (\n                    <scp>ADM<\/scp>\n                    ) in management of diabetic foot wounds in Singapore"],"prefix":"10.1111","volume":"22","author":[{"given":"Alison Mei Fern","family":"Quah","sequence":"first","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Jia Ming","family":"Ng","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7029-1358","authenticated-orcid":false,"given":"Yam Meng","family":"Chan","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufen","family":"Neo","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-0946","authenticated-orcid":false,"given":"Malcolm","family":"Mak","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-7049","authenticated-orcid":false,"given":"Qiantai","family":"Hong","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"},{"name":"Skin Research Institute of Singapore, Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Tan","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"},{"name":"Skin Research Institute of Singapore, Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"},{"name":"Skin Research Institute of Singapore, Agency for Science Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-0066","authenticated-orcid":false,"given":"Enming","family":"Yong","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of General Surgery Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i8.1684"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13540"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305\u20104179(95)93866\u2010i"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2003.12.016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.07.019"},{"key":"e_1_2_8_8_1","unstructured":"CG REALLO PUTTY. CGBIO_EN. Accessed August 7 2024.https:\/\/www.cgbio.co.kr\/en\/product\/wound\/cg-reallo-putty"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000416006.55218.d0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021\u20109150(03)00140\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000741512.57300.6d"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2013.02.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.24133"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.789274"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T01:24:36Z","timestamp":1737681876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/iwj.70127"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70127","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70127"}}