{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:13:21Z","timestamp":1783062801958,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>All common negative pressure wound therapy (NPWT) systems include a filler material usually foam or gauze at the wound\/device interface. The filler material distributes the negative pressure evenly to all parts of the wound. The foam or gauze may fragment contributing to foreign material being retained in the wound, becoming colonised with bacteria over time, and painful dressing changes. To mitigate these, negative aspects, an impermeable embossed single\u2010layer NPWT membrane dressing has been developed. The dressing has been coined Negative Pressure\u2014Platform Wound Device (NP\u2010PWD) and a foam or gauze is not required to deliver negative pressure. Rather, the pressure is permeated via the spaces between the embossed pyramids and the wrinkles in the membrane. The purpose of this study was to compare the NP\u2010PWD to the standard of care (SOC) NPWT system in the treatment of skin and soft tissue defects. This was a prospective, randomised, controlled clinical trial. The wounds were treated with the NP\u2010PWD or SOC NPWT system. The randomised treatment was applied for 2\u2009days to up to 9\u2009days after the initial application. Follow\u2010up data were collected at each dressing change\/removal and included photographs, and assessments for wound healing, infection, and adverse events. In total 24 subjects (12 NP\u2010PWD and 12 SOC) completed the study. The NP\u2010PWD was easy to use and fast to apply and the patients tolerated it well. The transparency of the NP\u2010PWD allowed the provider to see the wound without removing the dressing which is an improvement over traditional NPWT. In terms of wound healing, inflammation, pain, and infection, no differences were observed between the NP\u2010PWD and the SOC NPWT system. The NP\u2010PWD is a simplified, single component NPWT system eliminating the use of the filler material that commonly causes challenges during treatment.<\/jats:p>","DOI":"10.1111\/iwj.70144","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:20:36Z","timestamp":1746418836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Prospective, Controlled, Randomised, Clinical Study of Negative Pressure Device Without Foam or Gauze for Skin and Soft Tissue Defects"],"prefix":"10.1111","volume":"22","author":[{"given":"Kristo","family":"Nuutila","sequence":"first","affiliation":[{"name":"United States Army Institute of Surgical Research  JBSA Fort Sam Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Diaz","sequence":"additional","affiliation":[{"name":"Metis Foundation  San Antonio Texas 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