{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:51:12Z","timestamp":1792003872277,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Radiotherapy is recommended for G2\u2010G3 large soft tissue sarcoma in association with radical wide excision in order to improve the local control of disease, but side\u2010effects may develop early after radiation invalidating wound healing. We retrospective evaluated short\u2010 and long\u2010term clinically relevant outcomes after surgery of limb STS with or without radiotherapy. All 243 patients with limb STS treated at the Veneto Institute Oncology (Padua, Italy) in 2015\u20132022 were retrospectively included. Outcome measures were short\u2010 and long\u2010term wound complications, length of hospital stay and outpatient care time. Multivariable analyses were performed using linear regression models and logistic regression models. Overall, 87 patients received neoadjuvant radiotherapy, 64 received adjuvant radiotherapy and 92 underwent surgery alone. At short\u2010term, multivariable analysis identified neoadjuvant radiotherapy as a risk factor for prolonged length of hospital stay (MD 6.4\u2009days, 95%CI 3.9 to 9.0\u2009days) and short\u2010term wound complications (OR 3.45, 95%CI 1.82 to 6.62). At long\u2010term, neoadjuvant radiotherapy was a risk factor for long\u2010term wound complications (OR 4.87, 95%CI 2.48 to 9.84), and longer outpatient care time (MD 83\u2009days, 95%CI 41 to 126\u2009days); similarly, adjuvant radiotherapy was also a risk factor for long\u2010term complications (OR 5.20, 95%CI 2.57 to 10.95) and longer outpatient care time (MD 62\u2009days, 95%CI 19 to 106\u2009days). Radiotherapy in limb STS was associated with impaired short\u2010 and long\u2010term clinically relevant outcomes, potentially affecting quality of life and healthcare costs. Balancing with its well\u2010known oncological benefits, new clinical strategies are needed to contain cutaneous radiogenic side effects. The use of negative pressure therapy can play a key role in the prevention of wound complications in oncological patients.<\/jats:p>","DOI":"10.1111\/iwj.70175","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:03:58Z","timestamp":1748840638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Wound Healing Complication in Radio\u2010Treated Limb Soft Tissue Sarcoma Patients: A Single Referral Centre Experience"],"prefix":"10.1111","volume":"22","author":[{"given":"Silvia","family":"Dal Pos","sequence":"first","affiliation":[{"name":"Soft Tissue, Peritoneum and Melanoma Surgical Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcodomenico","family":"Mazza","sequence":"additional","affiliation":[{"name":"Soft Tissue, Peritoneum and Melanoma Surgical Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Maria","family":"Gianesini","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences (DISCOG) University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cavallin","sequence":"additional","affiliation":[{"name":"Independent Statistician  Solagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Del Fiore","sequence":"additional","affiliation":[{"name":"Soft Tissue, Peritoneum and Melanoma Surgical Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saveria","family":"Tropea","sequence":"additional","affiliation":[{"name":"Soft Tissue, Peritoneum and Melanoma Surgical Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Parisi","sequence":"additional","affiliation":[{"name":"Radiation Therapy Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Ghirelli","sequence":"additional","affiliation":[{"name":"Radiation Therapy Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Samaritana","family":"Buzzaccarini","sequence":"additional","affiliation":[{"name":"Radiation Therapy Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scarzello","sequence":"additional","affiliation":[{"name":"Radiation Therapy Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mocellin","sequence":"additional","affiliation":[{"name":"Soft Tissue, Peritoneum and Melanoma Surgical Oncology Unit Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"},{"name":"Department of Surgical, Oncological and Gastroenterological Sciences (DISCOG) University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.07.006"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.06.034"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3524"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-022-02166-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01191-4"},{"key":"e_1_2_12_8_1","unstructured":"AIOM \u201cLinee Guida SARCOMI DEI TESSUTI MOLLI E GIST \u201d2021 https:\/\/www.aiom.it\/wp\u2010content\/uploads\/2019\/10\/2019_LG_AIOM_Sarcomi\u20101.pdf."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-162"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4801.2005.00079.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(02)96494-2"},{"key":"e_1_2_12_12_1","first-page":"224","article-title":"Irradiatid Skin and Its Postsurgical Management","author":"Hom D. H. V.","year":"2009","journal-title":"Essential Tissue Healing of the Face and the Neck"},{"key":"e_1_2_12_13_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2023"},{"issue":"280","key":"e_1_2_12_14_1","first-page":"23","article-title":"Current Condition and Challenges in Treatment of Non\u2010Healing Wound After Radiation Therapy (Review)","author":"Karalashvili L.","year":"2018","journal-title":"Georgian Medical News"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000000371"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050516"},{"key":"e_1_2_12_17_1","first-page":"2875","article-title":"Postoperative Seromas After SoftTissue Sarcoma Resection: Natural History and Progression","volume":"5","author":"El Abiad J. M.","year":"2020","journal-title":"Clinics in Surgery"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/289673"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-020-01927-7"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12662"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.18332\/popmed\/165187"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"issue":"5","key":"e_1_2_12_24_1","first-page":"43","article-title":"Results of a One\u2010Day, Descriptive Study of Quality of Life in Patients With Chronic Wounds","volume":"54","author":"Shukla V. K.","year":"2008","journal-title":"Ostomy\/Wound Management"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70062-8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/21061"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup3.S1"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12318"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13654"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:40:00Z","timestamp":1754916000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/iwj.70175"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70175","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70175"}}