{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:58:12Z","timestamp":1792180692063,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Open incision negative pressure wound therapy (NPWT) combines delayed closure with negative pressure to prevent surgical site infection (SSI). Its effectiveness in preventing SSI remains unclear, complicating its risk\u2013benefit assessment. PubMed and Web of Science databases were searched for relevant English studies. Two reviewers independently screened titles and abstracts using the ASReviewer tool. Full\u2010text articles were assessed for eligibility. Eight studies were included in the systematic review and five were pooled in the meta\u2010analysis. Data extraction followed the PRISMA guidelines, and the risk of bias was assessed. A meta\u2010analysis was performed using a random\u2010effects model for SSI occurrence. Eight studies (three RCTs and five cohort studies) with 1655 patients were included. Studies were pooled based on control interventions: primary closure (PC) or delayed primary closure (DPC). Pooled odds ratio (OR) estimates favoured NPWT over PC for SSI reduction (OR, 0.15; 95% CI, 0.02\u20130.87). No significant SSI risk difference was found between the NPWT and DPC groups (OR, 0.28; 95% CI, 0.06\u20131.27). Preventive NPWT is associated with a reduced risk of SSI in abdominal surgery compared to PC. Our findings indicate that standardising treatment and reporting protocols could improve future evaluations of NPWT effectiveness.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> PROSPERO identifier: CRD42024401669<\/jats:p>","DOI":"10.1111\/iwj.70199","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:26:51Z","timestamp":1744766811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of Open Incision Negative Pressure Wound Therapy for Surgical Site Infection Prevention for Abdominal Surgery\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"22","author":[{"given":"Katarzyna","family":"Polomska","sequence":"first","affiliation":[{"name":"Department of Oncological, Transplant and General Surgery Medical University of Gdansk  Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Kowalik","sequence":"additional","affiliation":[{"name":"Department of Oncological, Transplant and General Surgery Medical University of Gdansk  Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarek","family":"Kobiela","sequence":"additional","affiliation":[{"name":"Department of Oncological, Transplant and General Surgery Medical University of Gdansk  Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Spychalski","sequence":"additional","affiliation":[{"name":"Department of Oncological, Transplant and General Surgery Medical University of Gdansk  Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"1","article-title":"Systematic Review and Meta\u2010Analysis of Wound Bundles in Emergency Midline Laparotomy Identifies That It Is Time for Improvement","volume":"11","author":"Mc Geehan G.","year":"2021","journal-title":"Life (Bethesda)"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-023-07093-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.03.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-021-02346-y"},{"key":"e_1_2_10_6_1","unstructured":"CDC Ncezid DHQP \u201cSurgical Site Infection Event (SSI) \u201d(2024) https:\/\/www.cdc.gov\/nhsn\/pdfs\/ps\u2010analysis\u2010resources\/ImportingProcedureData.pdf."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(99)70088-X"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2687-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.07.057"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract14010006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-023-01686-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-020-00287-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-072254"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_10_18_1","unstructured":"J. P. T.Higgins J.Thomas J.Chandler et al. \u201cCochrane Handbook for Systematic Reviews of Interventionsversion 6.5 (updated August 2024) \u201dCochrane(2024) www.training.cochrane.org\/handbook."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2023.10.055"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481708300528"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.04.018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2018.134"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2017.12.008"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12643"},{"issue":"3","key":"e_1_2_10_25_1","first-page":"114","article-title":"Efficacy of Negative Pressure Wound Therapy Followed by Delayed Primary Closure for Abdominal Wounds in Patients With Lower Gastrointestinal Perforations: Multicenter Prospective Study","volume":"4","author":"Ota H.","year":"2020","journal-title":"Journal of the American Society of Colon and Rectal Surgeons"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6767570"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.01.047"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481708300528"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14812"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2021.033"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.25270\/wmp.2021.6.1019"},{"key":"e_1_2_10_32_1","unstructured":"CDC Ncezid DHQP \u201cSurgical Site Infection Event (SSI) \u201d(2023) https:\/\/www.cdc.gov\/nhsn\/pdfs\/ps\u2010analysis\u2010resources\/ImportingProcedureData.pdf."},{"key":"e_1_2_10_33_1","unstructured":"ClinicalTrials.gov \u201cNPWT vs Primary Closure in SSI Prevention for Emergency Laparotomies for Peritonitis \u201dStudy Details (2024) https:\/\/clinicaltrials.gov\/study\/NCT05684198?term=polomska&rank=1."}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T06:41:59Z","timestamp":1746427319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/iwj.70199"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70199","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70199"}}