{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:32:33Z","timestamp":1791340353362,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030827","name":"Niilo Helanderin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This observational cohort study explored lymphoedema development following a cancer diagnosis and whether demographic factors impacted the time to lymphoedema development. We identified cases through the Secure Anonymised Information Linkage (SAIL) Databank. We used cancer diagnostic codes to identify a cohort of six broad cancer \u2018types\u2019. We independently used lymphoedema diagnostic codes to identify a cohort who developed lymphoedema. We linked these two cohorts to develop a single cohort of cases and describe the number of cases who went on to develop lymphoedema <jats:italic>after<\/jats:italic> a cancer diagnosis, and the time to lymphoedema diagnosis. We used Cox regression models to calculate hazard ratios and produced survival curves to explore whether pre\u2010defined factors (gender, age, deprivation, cancer type) had any impact on time to lymphoedema development. We identified 7538 cases of lymphoedema development after a cancer diagnosis, relating to 7279 people. There was considerable variation in the time to diagnosis, with a mean and standard deviation of 483.3 (701.8) days. Cancer type was the single most important factor in explaining time to lymphoedema diagnosis. Time to lymphoedema was shortest in breast cancer. A large number of breast cancer cases have undergone surgery, and this may account for the earlier development of lymphoedema. Consideration should be made of risk factors for lymphoedema development in order to allow for more targeted treatment plans that could improve health\u2010related quality of life for patients.<\/jats:p>","DOI":"10.1111\/iwj.70331","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T03:05:30Z","timestamp":1745550330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lymphoedema Development Following a Cancer Diagnosis: An Anonymised Data Linkage Study in Wales, United Kingdom"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-0179","authenticated-orcid":false,"given":"Ioan","family":"Humphreys","sequence":"first","affiliation":[{"name":"School of Health and Social Care, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Watkins","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-0801","authenticated-orcid":false,"given":"Ashley","family":"Akbari","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowena","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Lymphoedema UK Clinical Network Swansea Bay University Health Board  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gabe\u2010Walters","sequence":"additional","affiliation":[{"name":"Lymphoedema UK Clinical Network Swansea Bay University Health Board  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6631-9629","authenticated-orcid":false,"given":"Melanie","family":"Thomas","sequence":"additional","affiliation":[{"name":"Lymphoedema UK Clinical Network Swansea Bay University Health Board  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Pike","sequence":"additional","affiliation":[{"name":"Lymphoedema UK Clinical Network Swansea Bay University Health Board  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Williams","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Dobbs","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gibson","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain S.","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley A.","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358836X9800300209"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg126"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-6465(22)02667-6"},{"key":"e_1_2_10_5_1","volume-title":"Modern Treatment for Lymphoedema","author":"Casley\u2010Smith J. 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