{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:11:42Z","timestamp":1794003102106,"version":"4.8.0"},"reference-count":35,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To investigate a dimpled, non\u2010bordered foam dressing with a soft silicone wound contact layer, the research spans from bench (fluid handling performance) to bedside (clinical effectiveness on exuding chronic wounds). In\u00a0vitro methodology was used to monitor the fluid handling capacity and fluid retention capacity of the investigational dressing compared to other commercially available foam dressings according to standard EN 13726:2023. To provide complementary clinically relevant fluid handling results, more advanced laboratory tests were conducted using the FLUHTE (FLUid Handling Test Equipment) wound simulator. In a paired clinical investigation, moderately to highly exuding chronic wounds of patients had the investigational dressing applied as part of the wound management regime, and healing\u2010related parameters were assessed for up to six weeks. The investigational dressing significantly outperformed the other dressings in fluid dispersion ability. Overall, the investigational dressing performed well in terms of fluid handling, including under compression. In the clinical investigation, the use of the dressing was associated with substantial wound improvement, reductions in size and exudate levels, and improved patient quality of life scores. At the final visit, nine (13.2%) patients had wounds that had healed. There were no adverse device effects reported. Data from the advanced laboratory tests highlighted the substantial impact of dressing design on fluid handling performance. The investigational dressing effectively handled fluid, even when subjected to mechanical forces mimicking those that it would be subjected to in the clinical setting. The clinical results support the use of the dressing on moderately and highly exuding chronic wounds of various clinical origins.<\/jats:p>","DOI":"10.1111\/iwj.70414","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:54:02Z","timestamp":1747187642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bench to Bedside Evaluation of an Innovative, Non\u2010Bordered Foam Dressing for Use in Exudating Chronic Wounds"],"prefix":"10.1111","volume":"22","author":[{"given":"Hadar","family":"Lev\u2010Tov","sequence":"first","affiliation":[{"name":"Dr Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-3578","authenticated-orcid":false,"given":"Thomas","family":"Serena","sequence":"additional","affiliation":[{"name":"Serena Group Research  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Sigal","sequence":"additional","affiliation":[{"name":"Angel City Research  California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-4622","authenticated-orcid":false,"given":"Erik","family":"Nygren","sequence":"additional","affiliation":[{"name":"M\u00f6lnlycke Health Care AB  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13960"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12610"},{"key":"e_1_2_11_4_1","first-page":"3","article-title":"Wound Exudate and the Role of Dressings. A Consensus Document","volume":"5","author":"Expert Working Group; Satellite Expert Working Group","year":"2008","journal-title":"International Wound Journal"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2022.0021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0173"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2024.02.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14750"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.3.236"},{"issue":"5","key":"e_1_2_11_10_1","first-page":"671","article-title":"Exploring Exudate Viscosity: A Rheological Analysis of Wound Exudates","volume":"32","author":"Melotto G.","year":"2024","journal-title":"Journal of Wound Care"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14674"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2023.04.008"},{"key":"e_1_2_11_13_1","volume-title":"Aspects of Absorption, Moisture Vapour Transmission, Waterproofness and Extensiblity","author":"EN 13726:2003 Test Methods for Wound Dressings","year":"2023"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2019.08.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14787"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14861"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2020-0268"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01061.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.0198"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13985"},{"issue":"9","key":"e_1_2_11_21_1","first-page":"255","article-title":"The Effects of Gravity on the Fluid\u2010Handling Properties of Wound Dressings Covered With Compression Bandages: Results of a Pilot Laboratory Investigation","volume":"26","author":"Thomas S.","year":"2014","journal-title":"Wounds"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-206X(01)80003-6"},{"key":"e_1_2_11_23_1","first-page":"135","article-title":"Comparison of Digital Planimetry and Ruler Methods for the Measurement of Extraction Socket Wounds","volume":"59","author":"Ibraheem W. I.","year":"2023","journal-title":"Medicine (Kaunas)"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12578"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000703"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2008.07.22.45.53.c6592"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000431203.64591.2f"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00373"},{"key":"e_1_2_11_29_1","first-page":"227","article-title":"Dressing\u2010Related Trauma: Clinical Sequelae and Resource Utilization in a UK Setting","volume":"6","author":"Charlesworth B.","year":"2014","journal-title":"ClinicoEconomics and Outcomes Research"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13515"},{"key":"e_1_2_11_31_1","first-page":"1","article-title":"From Lab to Clinic: The Necessity of Realistic Testing Conditions in Evaluating Wound Dressing Performance","volume":"3","author":"Nygren E.","year":"2024","journal-title":"Wound Masterclass"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2005.14.7.26798"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1997.6.7.333"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1997.6.6.266"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1997.6.8.383"},{"key":"e_1_2_11_36_1","first-page":"42","article-title":"Comparing a Foam Composite to a Hydrocellular Foam Dressing in the Management of Venous Leg Ulcers: A Controlled Clinical Study","volume":"50","author":"Vanscheldt W.","year":"2004","journal-title":"Ostomy\/Wound Management"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:14:24Z","timestamp":1747188864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":35,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/iwj.70414"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70414","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70414"}}