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Physicians may recommend an ostomy as a temporary or permanent solution to a range of disorders of the gastrointestinal tract, with up to 130\u2009000 ostomies performed annually in the United States. An ostomy facilitates the expulsion of waste products, termed dejecta and circumvents the compromised organs. While an ostomy can be a lifesaving treatment, it is a disruption of regular digestive flow and has a number of associated complications including hernia, prolapse and necrosis. The most commonly observed complications are peristomal skin complications (PSCs), attributed to the leakage of dejecta onto the peristomal skin or the skin directly surrounding the stoma. Despite the prevalence of PSCs, little is known about the precise etiological factors that play a role in PSC formation. This review discusses the constituents of dejecta and their possible roles in PSC formation. Additionally, we identify a number of in\u00a0vitro and in\u00a0vivo skin models that could be used to study PSCs. Identification of the components of dejecta and understanding their interaction with skin models can facilitate the development of interventions to treat and prevent PSCs.<\/jats:p>","DOI":"10.1111\/iwj.70514","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T01:59:14Z","timestamp":1747879154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Understanding the Impact of Ostomy Dejecta Constituents on Peristomal Skin Health and Models for Its Characterisation"],"prefix":"10.1111","volume":"22","author":[{"given":"Mirella A.","family":"Ejiugwo","sequence":"first","affiliation":[{"name":"Tissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine Royal College of Surgeons in Ireland (RCSI)  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie V.","family":"Gawenda","sequence":"additional","affiliation":[{"name":"Tissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine Royal College of Surgeons in Ireland (RCSI)  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abram D.","family":"Janis","sequence":"additional","affiliation":[{"name":"Hollister Incorporated  Libertyville Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Department of Surgery Beaumont Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u00e9ad T.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Royal College of Surgeons in Ireland (RCSI)  Dublin Ireland"},{"name":"Department of Clinical Microbiology Beaumont Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-1712","authenticated-orcid":false,"given":"Shane","family":"Browne","sequence":"additional","affiliation":[{"name":"Tissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine Royal College of Surgeons in Ireland (RCSI)  Dublin Ireland"},{"name":"C\u00daRAM, Centre for Research in Medical Devices National University of Ireland  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/phrs.2021.1603990"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.11.303"},{"issue":"11","key":"e_1_2_16_4_1","first-page":"182","article-title":"Intestinal Ostomy","volume":"115","author":"Ambe P. 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