{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:31:48Z","timestamp":1788093108088,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chronic wounds pose significant challenges to patients and potentially reduce patients' quality of life. A prospective randomised control trial (RCT) was conducted in Russia between 2018 and 2021 to assess the effectiveness of treating chronic wounds with a high\u2010intensity Erbium: Yttrium Aluminium Garnet (Er:YAG with RecoSMA (Reconstructive Spatially Modulated Ablation module for distributing laser radiation into microbeams) laser technology versus sharp debridement in 144 patients (treatment group <jats:italic>N<\/jats:italic>\u2009=\u200971; control <jats:italic>N<\/jats:italic>\u2009=\u200973) with diabetic foot, venous and arterial leg ulcers. The median ulcer size at baseline in the treatment and control group was 11\u2009cm<jats:sup>2<\/jats:sup> and 10\u2009cm<jats:sup>2<\/jats:sup> with median ulcer duration of 16\u2009months and 15\u2009months, respectively. The endpoints were the time to achieve a clean wound bed, time to granulation, extent of complete and marginal epithelialisation, change in wound area, presence of bacteria, levels of topical wound pain, and the patients' tolerance of debridement. A difference at <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant. After a 30\u2010day observation period, complete epithelialisation occurred in more than twice as many wounds in the treatment group (56.3%) compared to the control group (26%). The Er:YAG laser was more effective than sharp debridement in clearing wounds of microbial flora, stimulating tissue regeneration, promoting early granulation, marginal epithelialisation and wound healing, suggesting that Er:YAG laser therapy may offer greater benefits than conventional methods of sharp debridement of slow healing wounds.<\/jats:p>","DOI":"10.1111\/iwj.70688","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T20:14:36Z","timestamp":1748290476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Erbium:Yttrium Aluminium Garnet (Er:<scp>YAG<\/scp>) Laser Therapy Versus Sharp Debridement in the Management of Chronic Ulcers of the Lower Extremity: A Randomised Control Trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-6870","authenticated-orcid":false,"given":"Alexander Evgenievich","family":"Zaitsev","sequence":"first","affiliation":[{"name":"Surgical Department, Branch No. 1 of the \u201c419 Military Hospital\u201d Ministry of Defence of Russia  Yeisk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-3932","authenticated-orcid":false,"given":"Oleg Nikolaevich","family":"Asanov","sequence":"additional","affiliation":[{"name":"Department of Surgery Military Medical Academy  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12822"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13708"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000377\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.06.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.1.20"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.sup12.s48"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13926"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12841"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/sap.0000000000000440"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12994"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.sup12.s10"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000003292"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.sup10a.s21"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2019.07.023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14320"},{"issue":"3","key":"e_1_2_10_17_1","first-page":"99","article-title":"Mechanisms of Laser\u2010Tissue Interaction: II. 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