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Non\u2010healing wounds can occur when clinicians fail to undertake an appropriate assessment, fail to recognise the importance of systemic or local complications, or provide the optimal treatment. The aetiological causes behind non\u2010healing wounds are multifactorial; however, the purpose of this article is to focus on the role of oxygen in non\u2010healing wounds and to introduce readers to advances in the delivery of topical oxygen therapy (TOT) via a haemoglobin spray. Importantly, this article incorporates a clinical decision support tool (CDST) to help clinicians identify the most appropriate individuals for whom topical haemoglobin may be most beneficial and the most appropriate time for introducing the intervention to improve wound healing outcomes.<\/jats:p>","DOI":"10.1111\/iwj.70700","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T02:53:30Z","timestamp":1748660010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Clinical Decision Support Tool for the Management of Diabetes\u2010Related Foot Ulcers (<scp>DRFUs<\/scp>) Using a Topical Haemoglobin Spray"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-0265","authenticated-orcid":false,"given":"Jose Luis","family":"Lazaro\u2010Martinez","sequence":"first","affiliation":[{"name":"Universidad Complutense de Madrid  Madrid 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