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Occupational fatigue and exhaustion were assessed using the OFER scale, while self\u2010efficacy in pressure injury (PI) management was evaluated using the PUM\u2010SES. Correlation and multiple linear regression methods were used for data analysis. The STROBE checklist was used in the study. The study included 682 nurses, 85.3% female. The average age was 29.99\u2009years, with a mean work experience of 7.52\u2009years. Most participants (70.7%) worked in public training and research hospitals, with 327 nurses working mixed day\u2010night shifts and 358 nurses managing 1\u20135 patients per shift. Fatigue levels, measured using the <jats:styled-content style=\"fixed-case\">OFER<\/jats:styled-content>, showed a mean score of 67.54 (22.89) for chronic fatigue. Self\u2010efficacy in pressure ulcer management, assessed using the <jats:styled-content style=\"fixed-case\">PUMSES<\/jats:styled-content>, had a mean score of 48.39 (24.87). Higher <jats:styled-content style=\"fixed-case\">PUMSES<\/jats:styled-content> scores were found among nurses with certification in stoma and wound care (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and those who had attended relevant training (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Significant correlations were identified between <jats:styled-content style=\"fixed-case\">OFER<\/jats:styled-content> recovery scores, professional characteristics and <jats:styled-content style=\"fixed-case\">PUMSES<\/jats:styled-content> scores. This study revealed that nurses experience moderate\u2010to\u2010high levels of occupational fatigue and low levels of self\u2010efficacy in PI management. Although no significant relationship was found between fatigue and self\u2010efficacy, occupational factors such as poor sleep quality, long working hours and irregular shift patterns were associated with increased fatigue. In contrast, higher educational attainment, greater knowledge about PI and participation in professional training significantly enhanced nurses' self\u2010efficacy in PI management. This study offers some early data on the possible role of occupational fatigue and PI preventive practices.<\/jats:p>","DOI":"10.1111\/iwj.70708","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T02:39:18Z","timestamp":1755139158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Nurses' Fatigue Level Affect Their Self\u2010Efficacy in Pressure Injury Management? 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