{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:59:22Z","timestamp":1755223162248,"version":"3.43.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Leishmania<\/jats:italic> spp. are intracellular protozoan parasites responsible for leishmaniasis, a globally prevalent vector\u2010borne disease transmitted by phlebotomine sandflies. Within vertebrate hosts, the parasites preferentially infect macrophages and dendritic cells, leading to cell lysis and the formation of disfiguring lesions. Current treatment regimens are hampered by high toxicity, prolonged administration protocols, and severe side effects, underscoring the need for safer and more effective therapeutic alternatives. Mesenchymal stem cells (MSCs), multipotent non\u2010haematopoietic progenitors with fibroblast\u2010like characteristics, possess self\u2010renewal capacity and the ability to differentiate into various functional cell types. Their intrinsic immunomodulatory and antimicrobial properties have positioned MSCs as promising candidates for combating infectious diseases, including leishmaniasis. This review systematically synthesises experimental evidence on the effects of MSCs on <jats:italic>Leishmania<\/jats:italic> parasites and the associated lesions, investigates the potential healing mechanisms of MSCs in the context of <jats:italic>Leishmania<\/jats:italic> infection, and outlines future research directions in this evolving field. A comprehensive literature search\u2014spanning Scopus, PubMed, Web of Science, and Google Scholar up to 31 May 2024\u2014identified 11 relevant studies: eight from Iran, two from Brazil, and one from Turkey. While Brazilian investigations utilised <jats:italic>L. amazonensis<\/jats:italic>, the others focused primarily on <jats:styled-content style=\"fixed-case\"><jats:italic>L. major<\/jats:italic><\/jats:styled-content>, a leading cause of cutaneous leishmaniasis (CL). Across these studies, MSC\u2010based therapy has shown immunomodulatory and antiparasitic effects, influenced by factors such as cell dosage, timing, route of administration, and the parasite burden. Despite promising findings, variability in experimental designs and outcomes highlights the early and exploratory stage of MSC application in CL therapy. Rigorous and standardised research is urgently needed to validate the therapeutic potential of MSCs and to support their clinical translation for leishmaniasis treatment.<\/jats:p>","DOI":"10.1111\/iwj.70709","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:14:58Z","timestamp":1749687298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal Stem Cells: A Double\u2010Edged Approach for Managing Cutaneous Leishmaniasis Lesions"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-7217","authenticated-orcid":false,"given":"Masoud","family":"Foroutan","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine Abadan University of Medical Sciences  Abadan 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