{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:46:00Z","timestamp":1793450760727,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aimed to compare the 3\u2010year recurrence rates of diabetic foot ulcers (DFU) and the rate of endovascular reintervention for chronic limb\u2010threatening ischaemia (CLTI) to recurrence rates of advanced\u2010stage cancers. We systematically collected original data reporting 3\u2010year DFU recurrence from studies published through 2024 and calculated a pooled mean. These findings were compared to recurrence rates for advanced breast, prostate, colorectal, and lung cancers using contemporary sources from the National Cancer Institute and American Cancer Society. CLTI reintervention data were drawn from the BEST\u2010CLI trial. The pooled 3\u2010year DFU recurrence rate was 58%, while the CLTI reintervention rate was 50%\u2014comparable to cancer recurrence rates: breast (25%\u201340%), prostate (30%\u201340%), colorectal (30%\u201350%), and lung (60%\u201380%). Despite these comparable risks, DFU and CLTI remain underrecognized in terms of their recurrent burden on individuals, families, and health systems. The data presented here underscore the need to reframe healed DFU and post\u2010intervention CLTI not as an endpoint but as a remission\u2014a state requiring structured surveillance and proactive management, much like in oncology. Developing interdisciplinary survivorship care plans for individuals with DFU and CLTI, modelled on those used in cancer care, may improve communication, enhance secondary prevention, and foster more ulcer\u2010free, hospital\u2010free, and activity\u2010rich days.<\/jats:p>","DOI":"10.1111\/iwj.70724","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:34:06Z","timestamp":1753227246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Three\u2010Year Recurrence in People With Diabetic Foot Ulcers and Chronic Limb Threatening Ischemia Is Comparable to Cancer"],"prefix":"10.1111","volume":"22","author":[{"given":"Natalie S.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"The National Academy of Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria A.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Division of Podiatric Surgery University of Texas Health Science Center  San Antonio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Mills","sequence":"additional","affiliation":[{"name":"The Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California san Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze\u2010Woei","family":"Tan","sequence":"additional","affiliation":[{"name":"Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery Keck School of Medicine of USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital Harvard Medical School  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery Keck School of Medicine of USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010022\u201005845\u20109"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05\u20102425"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010006\u20100491\u20101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jfa2.12013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047\u2010020\u201000383\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207899"},{"key":"e_1_2_9_11_1","first-page":"1","article-title":"The International Working Group on the Diabetic Foot: Stories and Numbers Behind Three Decades of Evidence\u2010Based Guidelines for the Management of Diabetes\u2010Related Foot Disease","volume":"15","author":"Netten J. 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