{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:55:49Z","timestamp":1790819749313,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR301807"],"award-info":[{"award-number":["NIHR301807"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There is an urgent need for effective interventions to aid diabetes\u2010related foot ulcer (DFU) healing. This study aimed to test the deliverability of a proposed trial of extracorporeal shockwave therapy (ESWT) for DFU healing. A pilot double\u2010blinded randomised controlled trial. Patients with a DFU present for \u2265\u20094\u2009weeks were randomised to high dose (500\u2009shocks\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ), low dose (100\u2009shocks\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) or sham (0\u2009shocks\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) ESWT, plus standard care. Follow\u2010up was for 24\u2009weeks. Primary outcome was deliverability of the trial. Secondary outcomes were healing, quality of life and healthcare resource use. One\u2010hundred and forty\u2010one (15.6%) screened patients were eligible and 74 (52.5%) patients were recruited. Follow\u2010up attendance was 97.3% (72\/74), 93.2% (69\/74) and 87.8% (65\/74) at 6, 12 and 24\u2009weeks. The median DFU healing time was high dose: 54.0 (IQR 119.0), low dose: 78.5 (IQR 61.0) and sham: 83.0 (IQR 85.0) days. The mean EQ\u20105D\u20105L utility value at 24\u2009weeks was high dose: 0.621 (95% CI 0.438\u20130.804), low dose: 0.779 (95% CI 0.683\u20130.876) and sham: 0.806 (95% CI 0.717\u20130.895). Healthcare resource use was lowest in the low\u2010dose ESWT arm. The pilot trial has demonstrated that patients with a DFU are willing to engage in the proposed trial and suggest the optimal way to deliver the definitive trial.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70740","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:09:28Z","timestamp":1764547768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Extracorporeal Shockwave Therapy for Diabetes Related Foot Ulcers: A Pilot Three\u2010Arm Double\u2010Blinded Randomised Controlled Trial"],"prefix":"10.1111","volume":"22","author":[{"given":"L.","family":"Hitchman","sequence":"first","affiliation":[{"name":"Faculty of Clinical Sciences, Hull York Medical School  Heslington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-5304","authenticated-orcid":false,"given":"R.","family":"Lathan","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences, Hull York Medical School  Heslington UK"},{"name":"Hull University Teaching Hospitals NHS Trust  Heslington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ravindhran","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences, Hull York Medical School  Heslington UK"},{"name":"Hull University Teaching Hospitals NHS Trust  Heslington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sidapra","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences, Hull York Medical School  Heslington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Long","sequence":"additional","affiliation":[{"name":"Hull University Teaching Hospitals NHS Trust  Heslington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cowling","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Keding","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Watson","sequence":"additional","affiliation":[{"name":"York Trials Unit, Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Smith","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences, Hull York Medical School  Heslington UK"},{"name":"Hull University Teaching Hospitals NHS Trust  Heslington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Twiddy","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Applied Sciences, Hull York Medical School  Heslington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-5618","authenticated-orcid":false,"given":"D.","family":"Russell","sequence":"additional","affiliation":[{"name":"Leeds Vascular Institute, Leeds Teaching Hospitals NHS Trust  Leeds UK"},{"name":"Leeds Institute of Clinical Trials Research, University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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