{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:18:46Z","timestamp":1790954326003,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel advanced synthetic bioactive glass matrix was studied in patients with non\u2010healing diabetic foot ulcers (DFUs). Bioactive glasses can be constructed to be biocompatible, with water\u2010soluble materials in multiple geometries including fibre scaffolds that mimic the 3D architecture of a fibrin clot. In this trial, chronic, Wagner Grade 1 DFUs were randomised to receive borate\u2010based bioactive glass Fibre Matrix (BBGFM) plus standard of care (SOC) therapy for 12\u2009weeks or SOC alone. The primary study endpoint was the proportion of subjects that obtained complete wound closure at 12\u2009weeks. Secondary endpoints included time to achieve complete wound closure at 12\u2009weeks. In the modified intent\u2010to\u2010treat (mITT) analysis, 48% (32\/67) treated with BBGFM plus SOC healed at 12\u2009weeks compared to 24% (16\/66) with SOC alone (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007). In the per protocol (PP) population, 73% (32\/44) of subjects treated with BBGFM plus SOC healed versus 42% (16\/38) in the SOC group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007). Based on the success of this trial, BBGFM demonstrates faster healing of DFUs compared to SOC and should be considered in the treatment armamentarium for Wagner Grade 1 DFUs. Future trials should investigate the use of BBGFM for healing deeper chronic DFUs, other wound aetiologies, or complex surgical wounds.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70763","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:11:07Z","timestamp":1758971467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Borate\u2010Based Bioactive Glass Advances Wound Healing in Non\u2010Healing Wagner Grade 1 Diabetic Foot Ulcers: A Randomised Controlled Clinical Trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-9175","authenticated-orcid":false,"given":"David G.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Department of Surgery Keck School of Medicine, University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-6483","authenticated-orcid":false,"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lantis","sequence":"additional","affiliation":[{"name":"Department of Surgery Mount Sinai Hospital, Ichan School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Glat","sequence":"additional","affiliation":[{"name":"Department of Surgery Drexel University School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Gitterle","sequence":"additional","affiliation":[{"name":"WoundCentrics, LLC  New Braunfels Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J.","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  Cody Wyoming USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Young","sequence":"additional","affiliation":[{"name":"Foot and Ankle Specialists of the MidAtlantic  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M.","family":"Zelen","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1614"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2176"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00383-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad255"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-8422(23)01025-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108113"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.Sup4b.S1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13759"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup1.S14"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13675"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.03.016"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/bglass\u20102015\u20100017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-005-0778-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/bglass-2019-0006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.11.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.232819"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1329510"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177950"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.03.014"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2738-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001151"},{"issue":"22","key":"e_1_2_10_25_1","first-page":"1050","article-title":"Treatment of Deep Wounds With Loss of Tissue. 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