{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:16:10Z","timestamp":1764029770146,"version":"3.45.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study evaluates the predictive value of the WIfI (Wound, Ischemia, and foot Infection) classification system and pre\u2010amputation transcutaneous oxygen pressure (TcPO2) measurements in forecasting post\u2010amputation complications in major lower limb amputations (MLLA). A retrospective analysis was conducted on 132 MLLA patients with complete WIfI data and 87 patients with documented TcPO2 values. Associations between WIfI stage, TcPO2, and post\u2010amputation outcomes\u2014including healing time, surgical revisions, re\u2010amputation, and wound complications\u2014were assessed using statistical modeling and receiver operating characteristic (ROC) curve analyses. Higher WIfI stages correlated with prolonged healing (WIfI 4 failure rate: 12.8%) but did not significantly predict complications. Unexpectedly, WIfI 2 patients had a 4.4\u2010fold higher risk of revision (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011) and a 3.1\u2010fold higher re\u2010amputation risk (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033) compared to WIfI 4. TcPO2 levels showed a significant relationship with healing outcomes, with a 36.9% failure rate in TcPO2\u2009&lt;\u200915\u2009mmHg. A TcPO2 cut\u2010off of &gt;\u200946\u2009mmHg optimized healing prediction (HR\u2009=\u20092.81,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). TcPO2 is a stronger predictor of post\u2010amputation complications than WIfI staging. A cut\u2010off of &gt;\u200946\u2009mmHg at the amputation site is recommended to improve healing outcomes.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70785","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:20:34Z","timestamp":1763140834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Post\u2010Amputation Complications in Major Lower Limb Amputations: The Role of\n                    <scp>WIfI<\/scp>\n                    Scoring and Pre\u2010Amputation Transcutaneous Oximetry (\n                    <scp>TcPO2<\/scp>\n                    )"],"prefix":"10.1111","volume":"22","author":[{"given":"Julian\u2010Dario","family":"Rembe","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf 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Endovascular Surgery Marien Hospital  Gelsenkirchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus U.","family":"Wagenh\u00e4user","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Schelzig","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waseem","family":"Garabet","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf 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