{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:16:09Z","timestamp":1764029769204,"version":"3.45.0"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The article describes the outcomes of a single\u2010centre investigation on the use of OZOILE to improve the healing process in patients with chronic diabetic ulcers. This is a non\u2010randomised interventional study which aims to assess the differences between two groups (total 200 patients) by evaluating healing time at 15, 30, 45, 60, 75 and 90\u2009days. Pain assessment with VAS scale at 15, 30 and 45\u2009days, biofilm test and tissue regeneration by histological evaluation were also taken into consideration. The outcomes show faster healing, reduced pain, control of local infection, aesthetically pleasing and qualitatively better healing. Our treatment strategy involves applying OZOILE detergent without rinsing, Ozoile spray oil and Ozoile cream followed by a non\u2010adherent dressing (paraffin gauze). This integrated protocol shows a safe and effective treatment for diabetic chronic wound healing in a cost\u2010effective manner. The group treated with the Rigenoma\/Ozoile protocol demonstrated significantly superior outcomes compared to the control group, including accelerated healing, reduced pain levels, effective management of unpleasant odour, and high levels of compliance from both patients and surgeons. Overall, Ozoile markedly reduced healing time compared with standard care, with results robust across multiple analytical approaches.<\/jats:p>","DOI":"10.1111\/iwj.70786","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:10:06Z","timestamp":1763701806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ozoile\u2010Stable Ozonides, Derived From Organic Extravirgin Olive Oil, Enhance Wound Healing Process in Patients With Diabetic Chronic Ulcers"],"prefix":"10.1111","volume":"22","author":[{"given":"Barbara","family":"De Angelis","sequence":"first","affiliation":[{"name":"Department of Surgical Science, Plastic and Reconstructive Surgery University of Rome Tor Vergata  Rome Italy"},{"name":"PhD Program in Applied Medical\u2010Surgical Sciences \u2010 Department of Surgical Sciences University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Plastic and Reconstructive Surgery University of Rome Tor Vergata  Rome Italy"},{"name":"PhD Program in Applied Medical\u2010Surgical Sciences \u2010 Department of Surgical Sciences University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Fernandes Lopes Morais D\u2019Autilio","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Plastic and Reconstructive Surgery University of Rome Tor Vergata  Rome Italy"},{"name":"PhD Program in Applied Medical\u2010Surgical Sciences \u2010 Department of Surgical Sciences University of Rome \u201cTor Vergata\u201d  Rome 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Scioli Maria","sequence":"additional","affiliation":[{"name":"Department of Anatomopathology Tor Vergata University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Department of Anatomopathology Tor Vergata University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"De Ninis","sequence":"additional","affiliation":[{"name":"\u201cLuisa D\u2019Annunzio\u201d Institute for High Culture  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Secondi","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Plastic and Reconstructive Surgery University of Rome Tor Vergata  Rome Italy"},{"name":"PhD Program in Applied Medical\u2010Surgical Sciences \u2010 Department of Surgical Sciences University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Cervelli","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Plastic and Reconstructive Surgery University of Rome Tor Vergata  Rome Italy"},{"name":"Department of Biomedicine and Prevention Tor Vergata University of Rome  Rome Italy"},{"name":"Chief of Plastic and Reconstructive Surgery University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, Plastic and Reconstructive Surgery University of Rome Tor Vergata  Rome Italy"},{"name":"PhD Program in Applied Medical\u2010Surgical Sciences \u2010 Department of Surgical Sciences University of Rome \u201cTor Vergata\u201d  Rome 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