{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:55:52Z","timestamp":1772913352403,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    EPIFIX, a dehydrated human amnion\/chorion membrane allograft, received regulatory approval as a medical device in 2021 by the Ministry of Health, Labour and Welfare following review by the Pharmaceuticals and Medical Devices Agency, for the treatment of refractory ulcers, including diabetic foot ulcers. Insurance reimbursement under the Japanese national health insurance system was approved in 2022. This study investigated the efficacy of EPIFIX for diabetic foot ulcers in Japan. This study included 55 patients who were treated with EPIFIX after debridement, evaluating the treatment duration and wound outcomes. Treatment was considered complete upon successful wound closure (i.e., reconstruction or epithelialization) or when adverse events (i.e., wound infection, death, or other complications) occurred. The wounds were classified as either healed or nonhealed. Wound healing was observed in 43 patients. Comparing the patients with healed and non\u2010healed wounds, there was a significant difference in the presence of chronic kidney disease (G5d), coronary artery disease, and certain laboratory findings (albumin, C\u2010reactive protein, white blood cell count, and haemoglobin) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The treatment duration was similar between the healed and non\u2010healed groups (24.39 vs. 24.83\u2009days,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.14). Wound bed preparation and an improved general health condition were key factors for healing. EPIFIX promotes wound healing in diabetic foot ulcers, although careful patient selection is essential to maximise its effectiveness.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70787","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:00:21Z","timestamp":1763460021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectivity of the Dehydrated Human Amnion\/Chorion Membrane Allograft for Diabetic Foot Ulcers in Japan: A Case Series"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-1006","authenticated-orcid":false,"given":"Yuta","family":"Terabe","sequence":"first","affiliation":[{"name":"Limb Salvage Center, Kasukabe Chuo General Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhito","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Limb Salvage Center, Kasukabe Chuo General Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2126"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2022.0064"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12140"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045\u2010824X\u20106\u201010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7547\/17\u2010039"},{"issue":"9","key":"e_1_2_11_8_1","first-page":"40","article-title":"Dehydrated Human Amnion\/Chorion Membrane as Adjunctive Therapy in the Multidisciplinary Treatment of Pyoderma Gangrenosum: A Case Report","volume":"61","author":"Snyder R. J.","year":"2015","journal-title":"Ostomy\/Wound Management"},{"key":"e_1_2_11_9_1","unstructured":"K.Tomikue \u201cResults of the 2019 \u2018National Health and Nutrition Survey\u2019 in Japan \u201dThe Ministry of Health Labor and Welfare 2019 https:\/\/tinyurl.com\/4sx867ue."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.01.020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12566"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12395"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13591"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12954"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12097"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12227"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:11:18Z","timestamp":1764029478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/iwj.70787"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70787","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70787"}}