{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:15:48Z","timestamp":1789708548448,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Irritant contact dermatitis is a common peristomal skin complication. Due to the continuous irritation from intestinal fluids and faeces, the healing of this dermatitis is slow and the condition severely impairs patients' quality of life. The study aimed to evaluate the efficacy of a modified insertable ostomy appliance in promoting healing and improving patient outcomes. A randomised controlled trial was conducted from January 2022 to December 2024 in a tertiary hospital. The enrolled patients, all diagnosed with irritant contact dermatitis, were randomly assigned to two groups. The control group wore the conventional two\u2010piece ostomy appliance, while the experimental group wore the modified insertable ostomy appliance. Outcomes were assessed on Days 3, 7, 14 and 28. The primary outcome was the healing rate (Discoloration, Erosion and Tissue overgrowth [DET] score \u2264\u20092) at Day 28. Secondary outcomes included the DET score, Visual Analogue Scale (VAS) pain score, Stoma Quality of Life questionnaire (Stoma\u2010QOL) score and the incidence of appliance leakage. A total of 89 eligible participants completed the trial. The experimental group showed a significantly higher 28\u2010day healing rate (73.3% vs. 29.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), lower DET scores (Day 28: 2.0 vs. 4.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), reduced VAS scores (Day 28: 1.5 vs. 2.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), higher Stoma\u2010QOL scores (Day 28: 55.67 vs. 51.64,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and lower leakage rate (13.3% vs. 93.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The modified ostomy appliance significantly improves healing, reduces pain and enhances quality of life, representing a novel solution for clinical practice.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70794","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T08:29:37Z","timestamp":1763195377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application and Efficacy Evaluation of a Modified Ostomy Appliance in Managing Peristomal Irritant Contact Dermatitis: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Xiaoxiao","family":"Ying","sequence":"first","affiliation":[{"name":"Ostomy Nursing Clinics Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Southeast University Affiliated Xuzhou Central Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4059-5737","authenticated-orcid":false,"given":"Chan","family":"Xu","sequence":"additional","affiliation":[{"name":"Ostomy Nursing Clinics Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11971-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0673-x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2025.109507"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WON.0000341473.86932.89"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljac122"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-097955"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03566.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2021.30.16.S22"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13710"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000003740"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/00494755251329636"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00152192-200501000-00008"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-019-01876-9"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nursrep15060206"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nursrep15030107"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13195673"},{"issue":"9","key":"e_1_2_12_18_1","article-title":"High\u2010Output Stoma Management: An Overview","volume":"112","author":"Heard R. S. M.","year":"2025","journal-title":"British Journal of Surgery"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15081151"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15069"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000001045"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10093.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006522"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.08.016"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijn.13045"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.077"},{"issue":"4","key":"e_1_2_12_27_1","first-page":"258","article-title":"Tacrolimus Ointment 0.1% for the Treatment of Peristomal Skin Disease: 3 Case Reports","volume":"78","author":"Wells G. 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