{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:57:21Z","timestamp":1784678241559,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic diabetic foot ulcers (DFUs) complicated by osteomyelitis remain a major clinical challenge, often requiring aggressive treatments or surgical intervention. Novel non\u2010invasive approaches such as laser and plasma therapy have shown promise in enhancing wound healing and reducing infection. As part of a broader study involving 20 patients with chronic DFUs (14 females and 6 males), a dual\u2010modality treatment combining low\u2010level laser therapy and PRP therapy was applied. Among the participants, two representative cases are presented in detail to highlight the clinical outcomes and treatment potential of this method. The first case involves a 65\u2010year\u2010old male with a chronic heel ulcer unresponsive to conventional therapies. The second case is a 58\u2010year\u2010old female with a necrotic toe and persistent ulceration. Treatment consisted of multiple sessions of laser and plasma therapy, integrated with standard wound care protocols. Progress was monitored through wound size, tissue regeneration, infection control, and overall healing response. Both patients demonstrated substantial clinical improvement, including resolution of necrotic tissue, reduction in wound size, and formation of healthy granulation tissue. No adverse effects were observed, and neither patient required surgical amputation. Further controlled studies are recommended to validate and generalise these findings.<\/jats:p>","DOI":"10.1111\/iwj.70796","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:27:07Z","timestamp":1764228427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Innovative Dual\u2010Modality Approach Using Laser and Plasma Therapy in the Management of Chronic Diabetic Foot Ulcer With Osteomyelitis: A Case Series"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4256-0881","authenticated-orcid":false,"given":"Fatemeh Harsij","family":"Sani","sequence":"first","affiliation":[{"name":"Wound Care Researcher, Omid Clinic  Chalus Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi Harsij","family":"Sani","sequence":"additional","affiliation":[{"name":"Internal Disease Specialist, Treata Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.12.773"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13577"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14856"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S433033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2023.05.045"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2023.49"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2024.108690"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/WOUND.2018.0842"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2020.107611"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119445821.ch30b"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u2010475X.2010.00619.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0016"},{"issue":"3","key":"e_1_2_10_14_1","first-page":"275","article-title":"Treatment of Diabetic Foot Ulcers","volume":"50","author":"Vuorisalo S.","year":"2009","journal-title":"Journal of Cardiovascular Surgery"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.12775\/qs.2024.21.44262"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"40","article-title":"Impact of Low Level Laser Therapy on Skin Blood Flow","volume":"20","author":"Podogrodzki J.","year":"2016","journal-title":"Developmental Period Medicine"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.4.580"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2023.2252075"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.09.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5978\/ISLSM.12.31"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.24061\/1727\u20100847.23.4.2024.70"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.21275\/sr23114133803"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102020\u2010136070"},{"issue":"3","key":"e_1_2_10_24_1","first-page":"888","article-title":"Efficacy of Local Autologous Platelet\u2010Rich Plasma in the Treatment of Chronic Ulcer","volume":"33","author":"Dubey D.","year":"2024","journal-title":"Mymensingh Medical Journal"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102016\u20100079"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.24018\/ejmed.2020.2.2.187"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00542\u2010015\u20102458\u2010y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.25259\/ijdvl_1290_2023"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP180220081S"},{"key":"e_1_2_10_30_1","unstructured":"M. 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