{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:17:00Z","timestamp":1773015420698,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011099","name":"Deutsche Gesellschaft f\u00fcr Internationale Zusammenarbeit","doi-asserted-by":"publisher","award":["34202421"],"award-info":[{"award-number":["34202421"]}],"id":[{"id":"10.13039\/501100011099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Patients with combat wounds and injuries, presented as extensive infected and purulent defects with antibiotic\u2010resistant microflora, were treated in a surgical inpatient setting. Closure of extensive soft tissue defects of the limbs is possible using methods of plastic and reconstructive surgery and requires preoperative infection control. The lack of effect from preoperative treatment for purulent limb defects with antibiotic\u2010resistant microflora leads to limb amputation. This clinical study proposes a method of treatment by hyperbaric oxygenation with an ozone\u2010containing steam\u2013water mixture as an anti\u2010bacterial agent. Eighteen male patients, aged between 20 and 60\u2009years, were categorised into three groups based on the time elapsed since the injury. All patients were treated using the proposed method. The high effectiveness of the proposed method was demonstrated in all groups and resulted in saving limbs from amputation, establishing suitable conditions for closing the soft tissue defects of the limbs and achieving significant progress in the recovery.<\/jats:p>","DOI":"10.1111\/iwj.70814","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:29:52Z","timestamp":1768008592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperbaric Oxygenation of an Ozone\u2010Containing Steam\u2013Water Mixture as Treatment of Infected Combat Wounds of the Limbs With Antibiotic\u2010Resistant Microflora"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-4058","authenticated-orcid":false,"given":"M. V.","family":"Kostyliev","sequence":"first","affiliation":[{"name":"O.O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-6561","authenticated-orcid":false,"given":"H. V.","family":"Terekhov","sequence":"additional","affiliation":[{"name":"O.O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-6080","authenticated-orcid":false,"given":"O. Yu.","family":"Furmanov","sequence":"additional","affiliation":[{"name":"O.O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3482-0206","authenticated-orcid":false,"given":"N. Yu.","family":"Hryhorieva","sequence":"additional","affiliation":[{"name":"Scientific\u2010Methodic Center \u201cMedical Innovative Technologies\u201d LLC  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2749-7825","authenticated-orcid":false,"given":"I. M.","family":"Savytska","sequence":"additional","affiliation":[{"name":"O.O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3526-9838","authenticated-orcid":false,"given":"Ye. V.","family":"Symulyk","sequence":"additional","affiliation":[{"name":"O.O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-5222","authenticated-orcid":false,"given":"L. A.","family":"Smitiukh","sequence":"additional","affiliation":[{"name":"O.O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Nevidkladna viiskova khirurhiia [Urgent Military Surgery]","author":"Chaplyk V.","year":"2024"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"72","article-title":"Mikrobiolohichna Struktura Ta Chutlyvist Patohennoi Mikroflory Do Antybiotykiv u Patsiientiv Iz Poranenniam Cherevnoi Porozhnyny [Microbiological Structure and Sensitivity of Pathogenic Microflora to Antibiotics in Patients With Abdominal Cavity Wounds]","volume":"16","author":"Kryshevskyi Y. P.","year":"2020","journal-title":"Medytsyna Nevidkladnykh Staniv"},{"issue":"5","key":"e_1_2_11_4_1","first-page":"99","article-title":"Predoperatsionnaya Podgotovka Infitsirovannykh Ran Poverkhnostnykh Tkaney Metodom Giperbaricheskoy Oksigenatsii Ozonsoderzhashchey Smes'yu [Preoperative Preparation of Infected Superficial Tissue Wounds Using Hyperbaric Oxygenation With an Ozone\u2010Containing Mixture]","volume":"88","author":"Chukhraev N. V.","year":"2021","journal-title":"Klinicheskaia Khirurgiia"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b02640"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101138"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163601"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1965.tb02146.x"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.70814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:15:41Z","timestamp":1773011741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/iwj.70814"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70814","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70814"}}