{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:57:50Z","timestamp":1790985470453,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim in this human trial is to compare the efficacy and safety of polygalacturonic\u2013caprylic acid (PG\u2013CAP) ointment to MediHoney in chronic wounds at three international medical centres. In this prospective open\u2010label study, patients with chronic full\u2010thickness wounds were randomised to daily treatment with PG\u2013CAP ointment or MediHoney. Assessments were obtained weekly for 6\u2009weeks. The validated Pressure Ulcer Scale for Healing (PUSH) score was used to track healing. Efficacies were compared using the Wilcoxon rank\u2010sum test for continuous variables and chi\u2010square or Fisher's exact test for categorical variables. Twenty\u2010six patients with chronic wounds were included. Baseline characteristics were comparable between the groups; however, the history of diabetes mellitus was higher in the PG\u2013CAP group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011). All 13 PG\u2013CAP patients showed improvement (100%), compared to only 69% of the 13 MediHoney patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Half of the failures in the MediHoney arm were associated with death (15%). No failures, adverse events or deaths occurred in the PG\u2013CAP arm. PG\u2013CAP wound ointment is a novel combination of two plant\u2010based compounds that pose minimal risk of promoting antimicrobial resistance, was highly effective for eradicating wound\u2010pathogen biofilms in\u00a0vitro and promoted chronic wound healing in\u00a0vivo with minimal inflammatory reactions. Our findings support PG\u2013CAP as safe, noninferior and possibly more effective than MediHoney in healing chronic contaminated wounds.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70815","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:42:59Z","timestamp":1769157779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Prospective Randomised Clinical Study Comparing Polygalacturonic and Caprylic Acid Ointment to Medical\u2010Grade Honey in the Management of Chronic Wounds"],"prefix":"10.1111","volume":"23","author":[{"given":"Hiba","family":"Dagher","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray Y.","family":"Hachem","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hakim","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery in the Department of Surgery The American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Husni","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases in the Department of Internal Medicine Lebanese American University School of Medicine and Medical Center\u2010Rizk Hospital  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diya' S.","family":"Hammoudeh","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery in the Department of Surgery The American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira Bou","family":"Karroum","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases in the Department of Internal Medicine Lebanese American University School of Medicine and Medical Center\u2010Rizk Hospital  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Hamerschlak","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Albert Einstein Israelite Hospital  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Ferraz","family":"Assir","sequence":"additional","affiliation":[{"name":"Albert Einstein Israelite Hospital  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janane","family":"Nasr","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases in the Department of Internal Medicine Lebanese American University School of Medicine and Medical Center\u2010Rizk Hospital  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-7186","authenticated-orcid":false,"given":"Joel","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliba","family":"Wehbe","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony M.","family":"Zeenny","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010Lan","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Chaftari","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odette","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery in the Department of Surgery The American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery in the Department of Surgery The American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rahman","family":"Bizri","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam I.","family":"Raad","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0329-y"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"issue":"3","key":"e_1_2_12_4_1","first-page":"44","article-title":"The Burden of Chronic Wounds in the UK","volume":"104","author":"Posnett J.","year":"2008","journal-title":"Nursing Times"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13071"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2012.11.008"},{"key":"e_1_2_12_7_1","unstructured":"C.Carver How to Identify Biofilm in a Wound 2015 https:\/\/www.woundsource.com\/blog\/how\u2010identify\u2010biofilm\u2010in\u2010wound."},{"issue":"2","key":"e_1_2_12_8_1","first-page":"1","article-title":"Management of Wound Biofilm Made Easy","volume":"8","author":"Bjarnsholt T. 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