{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:36Z","timestamp":1787755356990,"version":"build-2784847793"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020586","name":"storbyuniversitetet","doi-asserted-by":"publisher","award":["2255\u2010101"],"award-info":[{"award-number":["2255\u2010101"]}],"id":[{"id":"10.13039\/100020586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Venous leg ulcers occur due to chronic venous insufficiency in the lower extremities and are often difficult to heal. Platelet\u2010rich plasma and platelet\u2010rich fibrin are products that contain high concentrations of platelets. This systematic review evaluated the effectiveness, safety and cost\u2010effectiveness of these products for the treatment of venous leg ulcers. Guided by the 2020 Joanna Briggs Institute systematic review of effectiveness guideline, this review included original studies that investigated platelet\u2010rich plasma and platelet\u2010rich fibrin in the treatment of venous leg ulcers from databases including the Cochrane Library, Embase, Medline, CINAHL, PubMed, World Health Organisation International Clinical Trials Registry, Clinical Trials.gov and Australian New Zealand Clinical Trials Registry. Methodological quality was assessed using relevant appraisal checklists. Information related to general characteristics of included articles and relevant outcomes of interest were extracted and synthesised narratively. Of thirty\u2010six eligible studies, 24 studies used platelet\u2010rich plasma, eleven investigated fibrin\u2010rich plasma and one study used both platelet\u2010rich plasma and fibrin\u2010rich. Most studies reported these products were effective in promoting wound healing, reducing other symptoms, and were safe to use. The use of platelet\u2010rich plasma and platelet\u2010rich fibrin resulted in significantly higher healed venous leg ulcers compared to control using conventional treatment (RR: 2.93, 95% CI, 1.90\u20134.53,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). These products were safe to used topically and promoted to wound healing, reduced pain, either along or combined with other treatments. Platelet\u2010rich plasma and fibrin\u2010rich plasma improves wound healing and appears to be safe to use in the treatment of venous leg ulcers.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70830","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T01:30:58Z","timestamp":1768181458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effectiveness, Safety and Cost\u2010Effectiveness of Platelet\u2010Rich Plasma and Platelet\u2010Rich Fibrin in the Treatment of Venous Leg Ulcers: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-0138","authenticated-orcid":false,"given":"Ut T.","family":"Bui","sequence":"first","affiliation":[{"name":"School of Nursing, Centre for Healthcare Transformation, Faculty of Health Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3834-205X","authenticated-orcid":false,"given":"Christina N.","family":"Parker","sequence":"additional","affiliation":[{"name":"School of Nursing, Centre for Healthcare Transformation, Faculty of Health Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-8422","authenticated-orcid":false,"given":"Jane","family":"O'Brien","sequence":"additional","affiliation":[{"name":"School of Nursing, Centre for Healthcare Transformation, Faculty of Health Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Iren Mihaila","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Health and Nursing Science University of Agder  Kristiansand Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Glynn","sequence":"additional","affiliation":[{"name":"Kelvin Grove Library Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sezer","family":"Kisa","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy Michelle","family":"Princeton","sequence":"additional","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13848"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14272"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010029"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13296"},{"key":"e_1_2_10_7_1","article-title":"Compression for Preventing Recurrence of Venous Ulcers","volume":"3","author":"Moraes Silva M. 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