{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:39:20Z","timestamp":1790249960246,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There is a significant need for trials that evaluate the treatment of University of Texas (UT) grade 2 and 3 diabetic foot ulcers (bone, joint, or tendon exposed wounds). We undertook a trial looking at the effect of intact fish skin graft (IFSG) on these deep and difficult\u2010to\u2010heal ulcers. 262 patients Intent to Treat (ITT) patients with UT grade 2 and 3 DFUs were randomised to receive intact fish skin graft (IFSG) or a standardised treatment (SOC) that adhered to the International Working Group on the Diabetic Foot (IWGDF) guidelines. The secondary endpoints that were measured included wound area reduction (WAR), healing rates at 20 and 24\u2009weeks; closure rates by UT grade, perfusion, quality of life, pain reduction and IFSG safety. We report ITT (all randomised) (mITT previosly reported) The (WAR) at 12\u2009weeks was 65.53% for IFSG versus 30.82% for SOC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007). UT 2 wounds (60% of total) exhibited a closure rate of 47% versus 23% at 16\u2009weeks for IFSG versus SOC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0033). Target wound infections were comparable (39 vs. 37) and major outcomes were comparable during the 24\u2009week period (target\u2010limb amputations 8% vs. 7%). Time\u2010to\u2010heal favoured IFSG (restricted mean to 24\u2009weeks 17.31 vs. 19.37\u2009weeks; KM\/log\u2010rank significant; Cox HR 1.59). The in the treatment of deep complex diabetic foot wounds the addition of IFSG significantly improved the number of patients with total wound closure as well as the time to wound closure without increased risk of complications. This improvement in total wound closure and time to wound closure was noted across prior amputation status, quality of perfusion, and UT grade.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70847","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:39:49Z","timestamp":1772984389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intent to Treat Analysis of the Primary and Secondary Outcomes for the\n                    <scp>ODINN<\/scp>\n                    Intact Fish Skin Graft for Deep Diabetic Foot Wounds Trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Dured","family":"Dardari","sequence":"first","affiliation":[{"name":"Diabetology Department Center Hopitalier Sud Francilien  Corbeil\u2010Essonnes France"},{"name":"LBEPS, Universit\u00e9 D'evry, IRBA, Universit\u00e9 Paris Saclay  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Piaggesi","sequence":"additional","affiliation":[{"name":"Diabetic Foot Section, Department of Endocrinology and Metabolism University Hospital Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Potier","sequence":"additional","affiliation":[{"name":"Diabetology Department CHU Bichat\u2014Claude Bernard, AP\u2010HP  Paris France"},{"name":"Institut Necker\u2010Enfants Malades, Universit\u00e9 Paris Cit\u00e9, INSERM UMR\u2010S1151, CNRS UMR\u2010S8253  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Sultan","sequence":"additional","affiliation":[{"name":"Diabetology Nutrition Department, CHU Montpelier Universit\u00e9 de Montpellier  Montpellier France"},{"name":"Inserm, CNRS, Phymedexp, CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Diener","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Wound Competence Center Krankenhaus Bucholz  Buchholz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Francois","sequence":"additional","affiliation":[{"name":"Diabetology Department CHU de Reims H\u00f4pital Robert Debr\u00e9  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Dorweiler","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery University of Cologne, Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bouillet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology, CHU de Dijon Dijon University Hospital  Dijon France"},{"name":"INSERM Unit, LNC\u2010UMR 1231, University of Burgundy  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"M'Bemba","sequence":"additional","affiliation":[{"name":"Department of Diabetology, CHU Cochin H\u00f4pital Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Chaillous","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology\u2010Nutrition L'institut du Thorax, CHU de Nantes, University Hospital of Nante  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Clerici","sequence":"additional","affiliation":[{"name":"San Carlo Hospital  Paderno\u2010Dugnano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Diabetology CHU de Strasbourg \u2010 H\u00f4pital Civil  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Wetzel\u2010Roth","sequence":"additional","affiliation":[{"name":"Belegarzt Wertachkliniken  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Storck","sequence":"additional","affiliation":[{"name":"St\u00e4dtisches Klinikum Karlsruhe  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dereck","family":"Shi","sequence":"additional","affiliation":[{"name":"Independent Cosultant  Minneapolis Minnesota USA"},{"name":"Inpendent Statistical Consultants  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur","family":"Davidsson","sequence":"additional","affiliation":[{"name":"Independent Cosultant  Minneapolis Minnesota USA"},{"name":"Inpendent Statistical Consultants  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldur","family":"Baldursson","sequence":"additional","affiliation":[{"name":"Landspitali University Hospital  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmar","family":"Kjartansson","sequence":"additional","affiliation":[{"name":"Landspitali University Hospital  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Charpentier","sequence":"additional","affiliation":[{"name":"CERITD (Center for Study and Research for Improvement of the Treatment of Diabetes) Bioparc\u2010Genopole Evry\u2010Corbeil  Evry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-6512","authenticated-orcid":false,"suffix":"II","given":"John C.","family":"Lantis","sequence":"additional","affiliation":[{"name":"Mount Sinai West Hospital, Icahn School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2400171"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae287"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.70009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.9.2549"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/22094"}],"container-title":["International Wound 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