{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T02:02:49Z","timestamp":1774231369374,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Split\u2010thickness skin autografts are commonly used to treat extensive cutaneous defects. However, donor site morbidity, including pain, bleeding, and delayed epithelialization, remains a major clinical challenge. This study evaluates whether applying autologous platelet\u2010rich plasma (PRP) to the donor site improves healing outcomes. A prospective cohort study was conducted at a tertiary\u2010level academic hospital in Colombia. The study protocol was approved by the local Institutional Ethics Committee. Adult patients (&gt;\u200918\u2009years) undergoing split\u2010thickness skin grafts for trauma, burns, oncologic resections, or chronic ulcers were included. Two groups were compared: the PRP group, in which autologous platelet\u2010rich plasma was applied to the donor site, and the control group, which received standard wound care. The primary outcome was the quality of epithelialization at the donor site, while pain, assessed using the Numeric Rating Scale, was evaluated as a secondary outcome at multiple postoperative time points. Data were analysed using descriptive statistics and linear mixed\u2010effects models adjusted for potential confounders, with statistical significance set at\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05. A total of 46 patients were included (16 in the PRP group and 30 in the control group), with no significant demographic differences between groups. The PRP group demonstrated improved epithelialization quality, with lower Vancouver Scar Scale scores on postoperative days 7 and 14 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Patients treated with PRP also reported a reduction of up to 50% in postoperative pain during early assessments (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These effects were maintained throughout the follow\u2010up period, suggesting a sustained benefit of PRP on both healing quality and pain control. These findings suggest that autologous PRP application at split\u2010thickness skin graft donor sites may enhance early epithelialization quality and reduce postoperative pain compared with standard wound care. PRP appears to be safe and may represent a useful adjunct to promote improved wound healing and patient recovery in reconstructive surgery. However, larger randomised controlled trials are required to confirm these findings and to establish the clinical effectiveness of autologous PRP in this setting.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70852","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:00:56Z","timestamp":1773018056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Results of the Use of Platelet\u2010Rich Plasma in the Donor Site of Split\u2010Thickness Skin Grafts: An Exploratory Cohort Study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-2265","authenticated-orcid":false,"given":"Pedro Fabi\u00e1n","family":"Lopez\u2010Aldana","sequence":"first","affiliation":[{"name":"Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Hospital Universitario de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Dar\u00edo Alviar","family":"Rueda","sequence":"additional","affiliation":[{"name":"Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Hospital Universitario de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Andr\u00e9s Rueda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Hospital Universitario de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4228-4039","authenticated-orcid":false,"given":"Christian Camilo","family":"Tavera\u2010Sanabria","sequence":"additional","affiliation":[{"name":"Universidad Industrial de Santander  Bucaramanga Colombia"},{"name":"Hospital Universitario de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Camila Rojas","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Universidad\u00a0del\u00a0Rosario  Bogot\u00e1 D.C Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angie Marcela Vargas","family":"Duarte","sequence":"additional","affiliation":[{"name":"Universidad Industrial de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria Mar\u00eda Barbosa","family":"Tarazona","sequence":"additional","affiliation":[{"name":"Universidad Industrial de Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-5042","authenticated-orcid":false,"given":"Sergio Alejandro","family":"Gomez\u2010Ochoa","sequence":"additional","affiliation":[{"name":"Fundacion Cardiovascular de Colombia  Floridablanca 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