{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:43Z","timestamp":1787755363081,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic venous leg ulcers (CVLUs) affect 1%\u20133% of adults. Standard compression therapy achieves healing in only 40%\u201370% of cases at 24\u2009weeks. Evidence for hyperbaric oxygen (HBO) therapy remains controversial, with limited sham\u2010controlled trials. To evaluate whether adjunctive HBO improves healing of refractory CVLUs compared to standard care alone. Single\u2010centre, open\u2010label randomised trial of 80 adults with CVLUs that persisted &gt;\u20093\u2009months despite standard care (defined as &lt;\u200930% area reduction after 4\u2009weeks of compression therapy). All consecutive eligible patients were randomised to HBO (20 sessions at 2.4 ATA, 90\u2009min) plus standard care (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940) or standard care alone (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940). Primary outcome: percentage ulcer area reduction at day 30. Blinded assessors measured wounds, though participants knew their treatment allocation. HBO group had greater area reduction (62.1%\u2009\u00b1\u200922.1% vs. 41.7%\u2009\u00b1\u200921.5%; mean difference 20.4%, 95% CI: 10.1\u201330.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; Cohen's\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.95). Complete healing at 90\u2009days occurred in 62.5% vs. 30.0% (NNT\u2009=\u20093). TcPO\n                    <jats:sub>2<\/jats:sub>\n                    increased from 26.1\u2009\u00b1\u20096.3 to 150.3\u2009\u00b1\u200945.6\u2009mmHg in HBO group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Pain decreased more with HBO (\u0394VAS \u22125.0 vs. \u22121.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Three patients (7.5%) had mild ear barotrauma that resolved spontaneously. Main limitations were lack of sham control and 90\u2010day follow\u2010up. In this trial, adjunctive HBO was associated with faster short\u2010term healing of refractory venous ulcers &lt;\u200920\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    . However, the open\u2010label design and single\u2010centre setting limit confidence in these findings. Sham\u2010controlled multicentre trials with longer follow\u2010up are needed before recommending routine use.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70856","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:07:51Z","timestamp":1772982471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hyperbaric Oxygen Therapy for Chronic Venous Leg Ulcers: A Prospective Randomised Controlled Trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-3522","authenticated-orcid":false,"given":"Dragan","family":"Nikoli\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Novi Sad Novi Sad Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery University Clinical Center of Vojvodina Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janko","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad Novi Sad Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery University Clinical Center of Vojvodina Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Manojlovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad Novi Sad Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery University Clinical Center of Vojvodina Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavko","family":"Budinski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad Novi Sad Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery University Clinical Center of Vojvodina Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana Basta","family":"Nikoli\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad Novi Sad Serbia"},{"name":"Center for Radiology University Clinical Center of Vojvodina Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Batini\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Novi Sad Novi Sad Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery University Clinical Center of Vojvodina Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14272"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121739"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02456.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010029"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006898"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3115"},{"issue":"3","key":"e_1_2_11_10_1","first-page":"457","article-title":"Venous Leg Ulcers: Pathophysiology and Classification","volume":"22","author":"Serra R.","year":"2023","journal-title":"International Journal of Lower Extremity Wounds"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12814"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13048"},{"key":"e_1_2_11_13_1","first-page":"1902","article-title":"Venous Leg Ulcers","volume":"2016","author":"Nelson E. A.","year":"2016","journal-title":"BMJ Clinical Evidence"},{"key":"e_1_2_11_14_1","first-page":"CD000265","article-title":"Compression for Venous Leg Ulcers","volume":"11","author":"O'Meara S.","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00634.x"},{"key":"e_1_2_11_16_1","first-page":"1","article-title":"Hyperbaric Oxygen Treatment for Chronic Pain: A Review of Clinical Effectiveness and Guidelines","volume":"1","author":"Sutherland S.","year":"2019","journal-title":"CADTH Rapid Response Reports"},{"key":"e_1_2_11_17_1","first-page":"CD002303","article-title":"Compression for Preventing Recurrence of Venous Ulcers","volume":"9","author":"Nelson E. A.","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3233"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2023.01.068"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12657"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/15385744231162924"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16353-8"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801214"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221100891"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181fbe2bf"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00436.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.101309"},{"key":"e_1_2_11_28_1","first-page":"CD004123","article-title":"Hyperbaric Oxygen Therapy for Chronic Wounds","volume":"6","author":"Kranke P.","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"e_1_2_11_29_1","first-page":"295","article-title":"Lower Limb Chronic Wounds Treated With Hyperbaric Oxygen Therapy: A Systematic Review and Meta\u2010Analysis","volume":"20","author":"Zhao J. C.","year":"2021","journal-title":"International Journal of Lower Extremity Wounds"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03478.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00328.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199404000-00026"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1911"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1754"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2378"},{"issue":"3","key":"e_1_2_11_37_1","first-page":"173","article-title":"Design of Sham\u2010Controlled, Double\u2010Blind Trials of Hyperbaric Oxygen Therapy: A Narrative Review","volume":"48","author":"Lansdorp C. A.","year":"2018","journal-title":"Diving and Hyperbaric Medicine"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.70856","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T01:45:46Z","timestamp":1774230346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/iwj.70856"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70856","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70856"}}