{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T02:02:48Z","timestamp":1774231368445,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neoplastic foot ulcers are particularly challenging for dermatologists and specialists in hard\u2010to\u2010heal wounds because their location and comorbidities can delay accurate diagnosis. We performed a multicentre, retrospective study analysing clinical and histological data, focusing on neoplastic foot ulcers collected over the past 5\u2009years. We evaluated patients' demographic characteristics, clinical features, histological diagnosis, tumour onset and ulcer site. Statistical analyses were conducted using SPSS software, v.30. In total, 106 patients affected by foot skin ulcers were enrolled in the present protocol (52 women, 54 men). The mean age was 70.15\u2009years. In most cases, the neoplastic ulcer was due to primary tumour ulceration. The dorsum of the foot was the most common site of neoplastic ulcers (66%). From a clinical perspective, most lesions were classified as ulcerated nodules (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200958), ulcerated plaques (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098) or hypergranulating ulcers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200925), all with thickened, atypical edges. Histological diagnoses included melanoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200945), non\u2010melanoma skin cancers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934), benign tumours (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200918) and rarer malignancies (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099). A statistically significant correlation was found between histotype and clinical lesion type, and between age and histotype. The study provided preliminary data on the clinical and histological characteristics of neoplastic foot ulcers, warranting further exploration in a prospective, multicentre study.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70871","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:08:02Z","timestamp":1773018482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoplastic Foot Ulcers: A Multicentre Retrospective Study"],"prefix":"10.1111","volume":"23","author":[{"given":"Agata","family":"Janowska","sequence":"first","affiliation":[{"name":"Dermatology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Dini","sequence":"additional","affiliation":[{"name":"Dermatology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Dermatology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2","family":"Mori","sequence":"additional","affiliation":[{"name":"Dermatology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morganti","family":"Riccardo","sequence":"additional","affiliation":[{"name":"Section of Statistics University Hospital of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Monari","sequence":"additional","affiliation":[{"name":"UO di Dermatologia ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Michelerio","sequence":"additional","affiliation":[{"name":"SC Dermatologia Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Tognetti","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia AOU Senese  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia AOU Senese  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Merli","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Misciali","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9092-6183","authenticated-orcid":false,"given":"Federica","family":"Trovato","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata \u2013 Istituto di Ricovero e Cura a Carattere Scientifico (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Di Guardo","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata \u2013 Istituto di Ricovero e Cura a Carattere Scientifico (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata \u2013 Istituto di Ricovero e Cura a Carattere Scientifico (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Collina","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata \u2013 Istituto di Ricovero e Cura a Carattere Scientifico (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-7769","authenticated-orcid":false,"given":"Alessia","family":"Paganelli","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata \u2013 Istituto di Ricovero e Cura a Carattere Scientifico (IDI\u2010IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000720252.15291.18"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.70332"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02948-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2013.07.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup6.S1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.33.2.102"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2025053255"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2024.0046"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07194-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.03.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.147"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15010120"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112251"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0503"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.680407"},{"issue":"3","key":"e_1_2_10_17_1","first-page":"197","article-title":"Marjolin's Ulcer in Chronic Wounds \u2013 Review of Available Literature","volume":"21","author":"Bazali\u0144ski D.","year":"2017","journal-title":"Contemporary Oncology (Poznan)"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491922"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics4040062"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20187079"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2024.10.060"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004332"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000337"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/carm\/5112520"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588411X13008889959172"},{"issue":"4","key":"e_1_2_10_26_1","article-title":"Primary Cutaneous Leiomyosarcoma of the Lower Extremity: A Case Report and Literature Review","volume":"13","author":"Chalfant V.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.70706"},{"key":"e_1_2_10_28_1","volume-title":"StatPearls [Internet]","author":"Marietta M.","year":"2025"},{"issue":"10","key":"e_1_2_10_29_1","article-title":"Atypical Diabetic Foot Ulcer Turning Into Squamous Cell Carcinoma","volume":"2025","author":"Alzir M. S.","year":"2025","journal-title":"Journal of Surgery Case Reports"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.20.00094"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13020"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12550"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00180"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14235886"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.70871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T01:45:37Z","timestamp":1774230337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/iwj.70871"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70871","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70871"}}