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In recent years, the development of biopolymer\u2010based hydrogels has emerged as a promising strategy for preventing and managing RD. Among these, alginate and chitosan\u2010based hydrogels have attracted considerable attention due to their excellent biocompatibility, biodegradability, and wound\u2010healing properties. This comprehensive review highlights the therapeutic efficacy of alginate\/chitosan composite hydrogels in RD management. The unique physicochemical characteristics of these hydrogels, including moisture retention, oxygen permeability, and controlled drug release capabilities, make them ideal candidates for treating radiation\u2010induced skin injuries. Mechanistically, these hydrogels exert anti\u2010inflammatory, antioxidant, and antimicrobial effects while promoting re\u2010epithelialization and collagen, which are critical in skin repair. Preclinical studies revealed significantly reduced RD severity scores and histopathological improvements following hydrogel application. Although clinical translation remains limited, initial trials showed promising outcomes in human subjects. 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