{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:38:49Z","timestamp":1776994729803,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["0320220420"],"award-info":[{"award-number":["0320220420"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hyperbaric oxygen therapy (HBOT) enhances wound healing by promoting angiogenesis and reducing hypoxia. However, the role of air\u2010breaks\u2014intermittent exposures to ambient air during HBOT\u2014remains unclear. We investigated the effects of air\u2010breaks on HBOT\u2010mediated wound healing, particularly in combination with adipose\u2010derived stromal cells (ASCs). Full\u2010thickness wounds were created in C57BL\/6 mice (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200936) and assigned to control, HBOT (1\u2009h\/day, 2 ATA for 11\u2009days), or HBOT with a 10\u2010min air\u2010break groups. In a second experiment, we evaluated ASC treatment combined with HBOT and air\u2010breaks. Wound healing was assessed via gross examination, histology and gene expression analysis of collagen type 1 alpha 1 (\n                    <jats:italic>Col1a1<\/jats:italic>\n                    ), hypoxia\u2010inducible factor 1 alpha (\n                    <jats:italic>Hif1a<\/jats:italic>\n                    ) and tumour necrosis factor (\n                    <jats:italic>Tnf\u2010\u03b1<\/jats:italic>\n                    ). Compared with HBOT alone, air\u2010breaks significantly improved wound closure, epithelial regeneration and collagen deposition (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Gene analysis showed higher\n                    <jats:italic>Col1a1<\/jats:italic>\n                    expression and lower\n                    <jats:italic>Hif1a<\/jats:italic>\n                    and\n                    <jats:italic>Tnf\u2010\u03b1<\/jats:italic>\n                    levels in the air\u2010break group. In ASC\u2010treated wounds, air\u2010breaks further accelerated healing, enhancing collagen synthesis and reducing hypoxia and inflammation. These findings suggest that incorporating air\u2010breaks into HBOT protocols improves wound healing outcomes, both generally and in ASC\u2010based therapies, by modulating collagen production, hypoxia and inflammation, and could optimise HBOT efficacy, particularly in cell\u2010based regenerative therapies.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70890","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:56:28Z","timestamp":1774425388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Wound Healing Through Air\u2010Break Augmentation of Hyperbaric Oxygen Therapy Combined With Adipose\u2010Derived Stromal Cell Transplantation in a Murine Model"],"prefix":"10.1111","volume":"23","author":[{"given":"Eun Hee","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heewoong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Plastic and Reconstructive Surgery Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Program in Stem Cell Biology Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Eun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Yeon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-0237","authenticated-orcid":false,"given":"Ki Yong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Plastic and Reconstructive Surgery Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Plastic and Reconstructive Surgery Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000600"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12480"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12782"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-4162-11638"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118246"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00455.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.837464"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007029"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181fbe2bf"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.28920\/dhm50.1.75-76"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1934-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"issue":"3","key":"e_1_2_12_14_1","first-page":"349","article-title":"The Effect of Estrogen on Wound Healing in Rats","volume":"23","author":"Rajabi M. A.","year":"2007","journal-title":"Pakistan Journal of Medical Sciences"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1341562"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2016.0718"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00045.2008"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2008.09.004"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21503"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-209222"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101886"},{"issue":"2","key":"e_1_2_12_22_1","first-page":"212","article-title":"Enhancement of Wound Healing by Conditioned Medium of Adipose\u2010Derived Stromal Cell With Photobiomodulation in Skin Wound","volume":"14","author":"Park I. S.","year":"2021","journal-title":"International Journal of Stem Cells"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.70890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:04:19Z","timestamp":1776992659000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/iwj.70890"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70890","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"assertion":[{"value":"2025-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70890"}}