{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:39:14Z","timestamp":1776994754238,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Calcium sulphate (CS) is a fully synthetic, sterile, bioabsorbable biomaterial extensively applied for the management of infected tissues and postoperative dead spaces resulting from surgical interventions. Residual DS may facilitate hematoma accumulation and bacterial colonisation, thereby heightening the risk of surgical\u2010site infections. Within orthopaedic surgery, CS has been predominantly evaluated as a bone\u2010void filler and an off\u2010label antibiotic delivery vehicle\u2014particularly in arthroplasty revisions, chronic osteomyelitis, and open fractures\u2014yielding high rates of infection prophylaxis, bone regeneration, and low complication profiles. Commercially available as injectable \u2018pearls\u2019 or beads, CS permits local, sustained antibiotic elution while undergoing gradual biodegradation, thus obviating the need for secondary removal procedures. Over the last decade, Calcium Sulphate beads (CSBs) have transcended orthopaedics, gaining traction across general, vascular, and endocrine surgery disciplines for the prevention and treatment of complex wound infections. However, their application in plastic and reconstructive surgery remains underreported, despite the specialty's frequent engagement with complex soft\u2010tissue defects, bone exposure, suture dehiscence, and trauma\u2010related wounds vulnerable to infection. To our knowledge, this represents the first scoping review synthesising current evidence, clinical indications, and emerging roles of CSBs within plastic and reconstructive surgery.<\/jats:p>","DOI":"10.1111\/iwj.70903","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:52:48Z","timestamp":1776419568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic\u2010Loaded Calcium Sulphate Beads in Wound Management: A Scoping Review of Emerging Applications in Plastic and Reconstructive Surgery"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"Marcasciano","sequence":"first","affiliation":[{"name":"Unit of Plastic and Reconstructive Surgery, Department of Experimental and Clinical Medicine University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8808-1190","authenticated-orcid":false,"given":"M.","family":"Astolfi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery University Hospital of Messina \u201cAOU Gaetano Martino\u201d  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Nanni","sequence":"additional","affiliation":[{"name":"Unit of Plastic and Reconstructive Surgery, Department of Experimental and Clinical Medicine University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Royal Victoria Infirmary  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Russo","sequence":"additional","affiliation":[{"name":"Unit of Tropical and Infectious Disease University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9105-1839","authenticated-orcid":false,"given":"L.","family":"Losco","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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