{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:38:52Z","timestamp":1776994732172,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Burn injuries pose a significant challenge in resource\u2010limited settings, particularly during humanitarian crises. This study examines the epidemiology, management, and outcomes of burn patients at a tertiary hospital in Damascus, Syria, from 2021 to 2024. A single\u2010centre retrospective cohort study was conducted on 500 admitted burn patients. Data on demographics, injury characteristics, management, complications and mortality were analysed using descriptive statistics, chi\u2010square tests, Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    tests and binary logistic regression. The lethal area 50% (LA50) was estimated using the logistic regression equation: . The mean patient age was 20.5\u2009\u00b1\u200917.9\u2009years, with a male predominance (55%). Flame burns (72.4%) at home (87.6%) were most common. The mean total body surface area burned was 30.99%\u2009\u00b1\u200921.31%, with 68.6% being full\u2010thickness injuries. The complication rate was 91%, with infection being most prevalent. The overall mortality rate was 39%, with sepsis (56.4%) as the leading cause. Logistic regression identified larger burn area (OR\u2009=\u20091.152,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), full\u2010thickness depth (ref. partial thickness, OR\u2009=\u20090.281,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), older age and female gender as independent predictors of increased mortality. Deceased patients had significantly shorter hospital stays. LA50 was 42.63% for a 40\u2010year\u2010old male with a partial\u2010thickness flame burn and a 10\u2010day hospital stay; for a female with a full\u2010thickness flame burn under the same conditions, it was 27.43%. This study reveals an alarmingly high burden of burn injuries in a crisis\u2010affected setting, with extreme complication and mortality rates. The findings highlight the critical impact of extensive burns and sepsis, underscoring severe systemic constraints on care. Urgent context\u2010specific interventions to strengthen acute burn management, infection control, and prevention strategies are imperative.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70910","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:40:56Z","timestamp":1776386456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology, Management, and Alarmingly High Mortality of Burn Patients: A Retrospective Analysis From\u00a0a Resource\u2010Limited Tertiary Centre in Syria"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9132-2053","authenticated-orcid":false,"given":"Lorieh","family":"Domat","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Al\u2010Mouwasat University Hospital Damascus University  Damascus Syria"},{"name":"Faculty of Medicine Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7260-5613","authenticated-orcid":false,"given":"Adel","family":"Azar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Damascus University  Damascus Syria"},{"name":"Department of Otorhinolaryngology, Al\u2010Mouwasat University Hospital Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-8547","authenticated-orcid":false,"given":"Ahmad","family":"Alkheder","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Damascus University  Damascus Syria"},{"name":"Department of Otorhinolaryngology, Al\u2010Mouwasat University Hospital Damascus University  Damascus Syria"},{"name":"Faculty of Medicine Syrian Private University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4116-3415","authenticated-orcid":false,"given":"Diana","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Al\u2010Mouwasat University Hospital Damascus University  Damascus Syria"},{"name":"Faculty of Medicine Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7831-2200","authenticated-orcid":false,"given":"Jean","family":"Domat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Damascus University  Damascus Syria"},{"name":"Department of Otorhinolaryngology, Al\u2010Mouwasat University Hospital Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8705-9751","authenticated-orcid":false,"given":"Hanady","family":"Zwaraa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Damascus University  Damascus Syria"},{"name":"Department of Pediatric Surgery, Children University Hospital Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawnak","family":"Almidani","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Al\u2010Mouwasat University Hospital Damascus University  Damascus Syria"},{"name":"Faculty of Medicine Damascus University  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000010595"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9300"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irac096"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab037"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2022.43.5.20210923"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/iraa084"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0003682"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp\u20102025\u2010444"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2022.11.067"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3045"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.08.019"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"584","article-title":"Retrospective Epidemiological Study of Burn Injuries in 1717 Pediatric Patients: 10\u2009Years Analysis of Hospital Data in Iran","volume":"47","author":"Kazemzadeh J.","year":"2018","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaa027"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9136256"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.30476\/beat.2025.104399.1549"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12873\u2010022\u201000758\u20107"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2013.11.020"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2020.7.25141"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.04.014"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7240"}],"container-title":["International Wound 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