{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:05:48Z","timestamp":1779681948721,"version":"3.53.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pressure ulcers remain a major cause of morbidity in skilled nursing facility populations, where frailty and comorbid conditions hinder healing. Numerous studies have established Nitric oxide's role in tissue repair, angiogenesis, and infection control, suggesting therapeutic potential for nitric oxide in chronic wound healing. A retrospective observational cohort study was conducted using de\u2010identified data from skilled nursing patients presenting with pressure ulcers. Two matched cohorts (200 patients per group) were compared: Those treated with a nitric oxide\u2013delivering foam and historical controls receiving standard of care. Propensity score matching accounted for baseline wound size, stage, sex, comorbidities, and treatment start date. The primary endpoint was complete closure (epithelialized or had an area of zero) within 12\u2009weeks. Bayesian hierarchical hurdle\u2013gamma regression estimated treatment effects using posterior means and 95% credible intervals. Within 12\u2009weeks, closure or resolution rates had a significant benefit in the treatment group across most stages: 94% versus 79% for Stage 1, 80% versus 45% in Stage 2, 64% versus 28% in Stage 3, 39% versus 12% in unstageable, 34% versus 10% in Stage 4, and 67% versus 31% for Deep Tissue Pressure Injuries. Overall, 63% (95% CrI 50%\u201375%) of NODF\u2010treated wounds healed compared with 34% (21%\u201347%) of SOC wounds. Posterior probabilities of superior healing with NODF exceeded 99% for most comparisons.<\/jats:p>","DOI":"10.1111\/iwj.70911","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:49:31Z","timestamp":1777427371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Real\u2010World Data Analysis of Pressure Ulcer Healing With Nitric Oxide\u2010Delivering Foam Among Older Adults"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-3226","authenticated-orcid":false,"given":"Rhonda","family":"Sullivan","sequence":"first","affiliation":[{"name":"iWOC Nursing Foundation  Villa Rica Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6100-0828","authenticated-orcid":false,"given":"Zwelithini Mzwandile","family":"Tunyiswa","sequence":"additional","affiliation":[{"name":"Open Wound Research, LLC  Puyallup Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-3469","authenticated-orcid":false,"given":"Windy","family":"Cole","sequence":"additional","affiliation":[{"name":"Director of Wound Care Research Kent State University College of Podiatric Medicine  Independence Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-4679","authenticated-orcid":false,"given":"Lisa","family":"Gould","sequence":"additional","affiliation":[{"name":"Director of Research, South Shore Health Center for Wound Healing  Weymouth Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3177-3388","authenticated-orcid":false,"given":"Mervin","family":"Low","sequence":"additional","affiliation":[{"name":"CEO Newport Wound  Newport Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Prevention and Treatment of Pressure Ulcers\/Injuries: Clinical Practice Guideline. The International Guideline","author":"European Pressure Ulcer Advisory Panel, National Pressure Injury Advisory Panel, & Pan Pacific Pressure Injury Alliance","year":"2019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2020.04.003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13130"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.15386\/mpr\u20102531"},{"issue":"13","key":"e_1_2_12_6_1","first-page":"1","article-title":"Global, Regional and National Burden of Decubitus Ulcers in 204 Countries and Territories from 1990 to 2021: A Systematic Review","volume":"26","author":"Zhang S.","year":"2025","journal-title":"Front Public Health"},{"issue":"3","key":"e_1_2_12_7_1","first-page":"212","article-title":"An Unbrella Review of Systematic Reviews and Meta\u2010Analysis of Prevalence and Incidence of Pressure Injuries in the United States","volume":"26","author":"Graziadio S.","year":"2025","journal-title":"Journal of Wound Management"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00031348231158691"},{"issue":"3","key":"e_1_2_12_9_1","first-page":"246","article-title":"Factors Affecting Wound Healing in Individuals with Pressure Ulcers: A Retrospective Study","volume":"68","author":"Karahan A.","year":"2022","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/23089"},{"issue":"1","key":"e_1_2_12_11_1","first-page":"1","article-title":"Frailty and Comorbidity in Older Adults With and Without Diabetes and Chronic Leg Ulcer: A Cross\u2010Sectional Study","volume":"22","author":"Duluklu B.","year":"2025","journal-title":"Internal Wound Journal"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303259"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.0004"},{"issue":"1","key":"e_1_2_12_14_1","first-page":"20","article-title":"Pressure Ulcer Healing Trajectories and Factors Influencing Healing in a Long\u2010Term Care Population","volume":"43","author":"Sheean P. 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