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Extracorporeal shockwave therapy (ESWT) is a promising adjunct to promote healing. This study aimed to explore the potential cost\u2010effectiveness of ESWT in DFU healing. Early model\u2010based cost\u2010effectiveness analysis was undertaken. A de novo four\u2010state, 1\u2010day\u2009cycle, Markov model was developed. The perspective for the analysis was the UK's National Health Service (NHS) and Personal Social Services over a 1\u2010year time horizon. Input parameters were estimated from the literature. Low dose ESWT, high dose ESWT and standard care alone were evaluated by running a simulation of 1000 patients with one DFU. Deterministic, probabilistic and value of information analysis were undertaken. Deterministic analysis indicated high dose ESWT has the potential to be a dominant strategy (i.e., no incremental analysis was necessary), exhibiting higher QALYs and lower costs compared to low dose ESWT and standard care. 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A definitive study is warranted to estimate ESWT's effectiveness and related HRQoL scores.<\/jats:p>","DOI":"10.1111\/iwj.70925","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:23:26Z","timestamp":1779668606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Early Trial\u2010Based Cost\u2010Effectiveness Analysis of Extracorporeal Shockwave Therapy for Diabetes Related Foot Ulcer Healing"],"prefix":"10.1111","volume":"23","author":[{"given":"L.","family":"Hitchman","sequence":"first","affiliation":[{"name":"Faculty of Clinical Sciences Hull York Medical School  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lathan","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences Hull York Medical School  Hull UK"},{"name":"Hull University Teaching Hospitals NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ravindhran","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences Hull York Medical School  Hull UK"},{"name":"Hull University Teaching Hospitals NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sidapra","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences Hull York Medical School  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Long","sequence":"additional","affiliation":[{"name":"Hull University Teaching Hospitals NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Smith","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences Hull York Medical School  Hull UK"},{"name":"Hull University Teaching Hospitals NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Twiddy","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Applied Health Research, Hull York Medical School  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Russell","sequence":"additional","affiliation":[{"name":"Leeds Vascular Institute, Leeds Teaching Hospitals NHS Trust  Leeds UK"},{"name":"Leeds Institute of Clinical Trials Research, University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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