{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:09:42Z","timestamp":1789085382830,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcers (DFUs) are serious complications of diabetes, characterised by impaired healing driven in part by pro\u2010inflammatory macrophage activity. ON101, a topical macrophage\u2010modulating cream, promotes M1\u2010to\u2010M2 transition and improves wound healing. We prospectively enrolled patients with Wagner Grade 2 DFUs and mild infection per the Infectious Diseases Society of America criteria to receive ON101 with weekly follow\u2010up. Exclusions included dialysis dependence and inadequate arterial perfusion. The primary endpoint was a 4\u2010week healing outcome. The secondary analysis compared direct costs to a 1:1 retrospective standard of care cohort matched on wound locations and natural history. A total of 12 cases were analysed (mean age: 65.8\u2009years in the ON101 group; 64.6\u2009years old in the control group,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.957). No adverse events occurred. The mean paired difference at the 4\u2010week healing outcome of ON101 was an 87% reduction (95% bootstrap CI: 9.0\u2013244.0) versus the control group. Direct cost per wound healed was approximately 19% lower with ON101. Subjects receiving ON101 demonstrated a significantly faster wound\u2010healing rate within 4\u2009weeks. The direct cost difference between ON101 and SOC mirrored lower resource use. A larger, randomised study with longer follow\u2010up is required to determine the robustness, generalisability and durability of these preliminary results.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70937","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T01:10:38Z","timestamp":1778461838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010Randomised Comparative Analysis and Cost\u2010Minimisation Analysis of Macrophage\u2010Modulating Cream on Mildly Infected Diabetic Foot Ulcers: A Real\u2010World Preliminary Report"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9203-1899","authenticated-orcid":false,"given":"Chia\u2010Ding","family":"Shih","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery and Endovascular Therapy Keck Medicine of USC  Los Angeles California USA"},{"name":"Casa Colina Hospital and 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Healthcare  Pomona California USA"},{"name":"Global Medicine Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Rosario","sequence":"additional","affiliation":[{"name":"Casa Colina Hospital and Centers for Healthcare  Pomona California USA"},{"name":"Global Medicine Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"International Diabetes Federation \u201cFacts & Figures \u201dpublished November 24 2022 https:\/\/idf.org\/about\u2010diabetes\/diabetes\u2010facts\u2010figures\/."},{"key":"e_1_2_12_3_1","unstructured":"CDC \u201cNational Diabetes Statistics Report \u201dDiabetes published July 23 2024 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