{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:48:55Z","timestamp":1791384535768,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Scalp follicular unit (FU) transplantation is a highly effective yet underutilised minimally invasive technique for promoting healing in chronic and recalcitrant cutaneous wounds. In this case series, five patients with long\u2010standing nonhealing leg ulcers of mixed etiologies were treated exclusively with single FU grafts harvested from the scalp with a 0.9\u20131\u2010mm punch. Complete re\u2010epithelialization occurred in three cases by 6, 3 and 1\u2009month, respectively, while the remaining two cases showed marked partial improvement at 6\u2009months, with reduction in ulcer area and pain. Overall, all five patients experienced a favourable clinical outcome. Case reports suggest that the transplantation of a minimum of 4 FU grafts\/cm\n                    <jats:sup>2<\/jats:sup>\n                    is required to promote effective wound closure, with higher graft densities being associated with faster healing. However, the optimal graft density and placement, whether uniform distribution or targeting the wound edge to exploit an \u2018edge effect\u2019, require further investigation. Considered alongside prior reports, these results suggest that 1\u2010mm single\u2010FU grafting achieves wound healing comparable to, and often faster than, 2\u20133\u2010mm punch grafts. Additionally, the technique is less invasive and causes less bleeding, overall supporting wider use as an adjunct in multidisciplinary wound care.\n                  <\/jats:p>\n                  <jats:p>Level of Evidence: IV<\/jats:p>","DOI":"10.1111\/iwj.70973","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:28:57Z","timestamp":1781180937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Hair to Healing: Follicular Unit Transplantation for Chronic Ulcer Management\u2014A Case Series"],"prefix":"10.1111","volume":"23","author":[{"given":"Francisco","family":"Jimenez","sequence":"first","affiliation":[{"name":"Mediteknia Clinic  Las Palmas de Gran Canaria Spain"},{"name":"Facultad de Ciencias de la Salud Universidad Fernando Pessoa Canarias  Las Palmas de Gran Canaria Spain"},{"name":"Cl\u00ednica CDI\/Ruber Internacional  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc.  London Ontario Canada"},{"name":"Division of Dermatology, Department of Medicine Temerty Faculty of Medicine, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Cooley","sequence":"additional","affiliation":[{"name":"Cooley Hair Center  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Pe\u00f1a\u2010Escobar","sequence":"additional","affiliation":[{"name":"Unidad Cirug\u00eda Pl\u00e1stica, Hospital de Cl\u00ednicas, Universidad Nacional de Asunci\u00f3n  San Lorenzo Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-640X","authenticated-orcid":false,"given":"Mesbah","family":"Talukder","sequence":"additional","affiliation":[{"name":"School of Pharmacy, BRAC University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u2010481X.2010.00660.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12927"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000227739.23850.4a"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2009.01308.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000760202"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2319"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2023.08.012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.24875\/pjd.m22000013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2020.11.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100041"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001748"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_38_17"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.02.1161"},{"issue":"4","key":"e_1_2_10_15_1","first-page":"109","article-title":"Optimizing Skin Grafting Using Hair\u2010Derived Skin Grafts: The Healing Potential of Hair Follicle Pluripotent Stem Cells","volume":"28","author":"Fox J. 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