{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:28:46Z","timestamp":1792621726425,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Wound healing is a complex process of angiogenesis, inflammation and proliferation relying on co\u2010ordination of multiple cell types and cytokines. Dysregulation of this process can lead to chronicity, which we are seeing more commonly due to an increasingly comorbid population. Adipose\u2010Derived Stem Cells (ADSCs) show promise as a therapy though their ability to augment the tissue microenvironment via multiple pathways. This review aims to synthesise evidence on the effects of ADSCs on chronic wound healing to assess their efficacy. A systematic search of four databases was conducted covering a period up to June 2025. Comparative studies investigating ADSCs and wounds of any aetiology were included, and a meta\u2010analysis was performed on pooled data. Ten studies were included in the meta\u2010analysis (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009498). Patients treated with ADSCs were more likely to heal at short\u2010term follow\u2010up (odds ratio (OR) 6.54, 95% confidence interval (CI) 3.80\u201311.27;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009377\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.00%\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.00) and healed significantly faster (mean difference \u22121.90, CI \u22122.28, \u22121.51;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009210,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200923.58,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.00) than controls. Grades of recommendation, Assessment, Development and Evaluation assessment showed this evidence is of moderate certainty. This review presents clinical evidence that ADSC use is a safe therapy which expedites the healing of wounds from multiple aetiologies.\n                  <\/jats:p>","DOI":"10.1111\/iwj.70986","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:09:01Z","timestamp":1783926541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Adipose Derived Stem Cells in Chronic Wound Healing"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0134-3296","authenticated-orcid":false,"given":"Si\u00f4na M.","family":"Ladley","sequence":"first","affiliation":[{"name":"Warwick Medical School University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyran","family":"Naghdi","sequence":"additional","affiliation":[{"name":"Warwick Clinical Trials Unit, Warwick Medical School  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Advanced Wound Care: Develop New Treatments in the UK","author":"Trade DfI","year":"2018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-7397-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12173"},{"key":"e_1_2_10_5_1","volume-title":"Chronic Wounds: Learn More\u2014What Are the Treatment Options for Chronic Wounds","author":"Care IfQaEiH","year":"2022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.06.058"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"e_1_2_10_8_1","volume-title":"Leg Ulcer\u2014Venous","author":"CKS N","year":"2024"},{"key":"e_1_2_10_9_1","unstructured":"NICE \u201cChronic Wounds: Advanced Wound Dressings and Antimicrobial Dressings \u201d2016 https:\/\/www.nice.org.uk\/advice\/esmpb2\/resources\/chronic\u2010wounds\u2010advanced\u2010wound\u2010dressings\u2010and\u2010antimicrobial\u2010dressingspdf\u20101502609570376901."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2012.04.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1634"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03389-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1030288"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.057"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001924"},{"issue":"8","key":"e_1_2_10_16_1","first-page":"1659","article-title":"Autologous Fat or Adipose\u2010Derived Stem Cell Grafting in Systemic Sclerosis Treatment: A Systematic Review and Meta\u2010Analysis","volume":"41","author":"Cao Y. 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