{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:44:38Z","timestamp":1785725078001,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic lower\u2010extremity ulcers remain a major therapeutic challenge. Conventional treatments\u2014including compression therapy, debridement, dressings, antibiotics, pharmacologic agents, hyperbaric oxygen, and skin grafting\u2014frequently fail to provide durable closure, largely due to limited modulation of the wound\u2010healing cascade. Autologous platelet\u2010rich plasma (PRP) is gaining interest as a regenerative adjunct capable of delivering concentrated endogenous growth factors. We report a 58\u2010year\u2010old woman with more than 20 previous skin grafting procedures for recurrent lower\u2010leg ulcers, arising from self\u2010inflicted trauma and secondary infections. Multidisciplinary care of a 15\u2009cm\u2009\u00d7\u200918\u2009cm ulcer incorporating debridement, targeted antibiotics, and mainly PRP, administered in six sessions, contributed substantially to ulcer reduction and finally to complete wound healing. PRP has shown promise in enhancing wound closure rates, healing time, and tissue quality. However, the absence of standardized protocols for preparation, dosing, and application, as well as inconsistent outcome reporting, limits its broader adoption. This case underscores the potential role of PRP as a central component in managing complex, refractory ulcers, particularly when behavioural and infectious factors impede healing. Standardized protocols and robust clinical trials are warranted to clarify its role in chronic wound care.<\/jats:p>","DOI":"10.1111\/iwj.70988","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:57:27Z","timestamp":1782727047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet\u2010Rich Plasma in a Refractory Venous Leg Ulcer Following Multiple Failed Skin Grafts"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1844-1264","authenticated-orcid":false,"given":"Konstantinos","family":"Seretis","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Medical School University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Peponi","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Medical School University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1243-5346","authenticated-orcid":false,"given":"Nikolaos","family":"Bounas","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Medical School University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroditi","family":"Vergidou","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Medical School University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Christaki","sequence":"additional","affiliation":[{"name":"First Division of Internal Medicine &amp; Infectious Diseases Unit University General Hospital of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2021.03.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/aam.aam_235_24"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.112671"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13361"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14736"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2024.07.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1154567"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/23107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.17-OR-17"},{"key":"e_1_2_10_11_1","article-title":"Meta\u2010Analysis of Platelet\u2010Rich Plasma in the Treatment of Lower Extremity Venous Ulcer","volume":"24","author":"Du Y.","year":"2024","journal-title":"Alternative Therapies in Health and Medicine"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2026.01.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12912"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2025.08.012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2014.0245"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02397-4"},{"issue":"11","key":"e_1_2_10_17_1","first-page":"1328","article-title":"Ultrapulsed Fractional CO2 Laser for the Treatment of Post\u2010Traumatic and Pathological Scars","volume":"9","author":"Cervelli V.","year":"2010","journal-title":"Journal of Drugs in Dermatology"},{"issue":"11","key":"e_1_2_10_18_1","article-title":"A Comprehensive Review on Platelet\u2010Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing","volume":"15","author":"Patel H.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15236"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.70988","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:53:31Z","timestamp":1785722011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/iwj.70988"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70988","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2026-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70988"}}