{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:11:16Z","timestamp":1790334676448,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To compare clinical and laboratory characteristics of transfusion\u2010dependent and non\u2010transfusion\u2010dependent beta thalassaemia patients with leg ulcers, and to identify contributing and protective factors We retrospectively reviewed 12 patients with beta thalassaemia and leg ulcers (seven transfusion\u2010dependent and five non\u2010transfusion\u2010dependent) at a tertiary centre. We analysed demographics, haemoglobin levels, ferritin, foetal haemoglobin, transfusion status, comorbidities, and ulcer characteristics. Transfusion\u2010dependent patients were predominantly younger males (mean age: 31.9\u2009years), while non\u2010transfusion\u2010dependent patients were older (mean age: 44.0\u2009years). Ulcers were larger in transfusion\u2010dependent patients (mean area: 3.1\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    ) but more frequent in non\u2010transfusion\u2010dependent patients (mean episodes: 2.2). Splenectomy was performed in all transfusion\u2010dependent patients and most non\u2010transfusion\u2010dependent patients. Transfusion\u2010dependent patients had higher ferritin levels, while non\u2010transfusion\u2010dependent patients had higher foetal haemoglobin and slightly better ulcer resolution rates (80% vs. 71%). Major exacerbating factors included chronic anaemia, iron overload, trauma, and hypercoagulability. Protective factors included higher foetal haemoglobin levels, hydroxyurea use, occasional transfusions, and early conservative wound care. Although more commonly reported in non\u2010transfusion\u2010dependent patients, leg ulcers were also clinically significant in transfusion\u2010dependent patients, where they were associated with larger ulcer size, higher iron burden, and incomplete healing despite regular transfusion and chelation. These findings highlight the need for heightened recognition and tailored preventive strategies for leg ulcers in transfusion\u2010dependent thalassaemia.\n                  <\/jats:p>","DOI":"10.1111\/iwj.71038","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:09:47Z","timestamp":1790312987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leg Ulcers in Thalassaemia: A Comparative Retrospective Review of Transfusion\u2010Dependent and Non\u2010Transfusion\u2010Dependent Patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5432-6363","authenticated-orcid":false,"given":"Sacha","family":"El Khoury","sequence":"first","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7877-3086","authenticated-orcid":false,"given":"Nicole","family":"Charbel","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7341-3244","authenticated-orcid":false,"given":"Farouk","family":"Kabbara","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5484-6706","authenticated-orcid":false,"given":"Joseph","family":"Klim","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8759-3895","authenticated-orcid":false,"given":"Ghida","family":"Ismail","sequence":"additional","affiliation":[{"name":"Chronic Care Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9023-7924","authenticated-orcid":false,"given":"Farah","family":"Ismail","sequence":"additional","affiliation":[{"name":"Chronic Care Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Koussa","sequence":"additional","affiliation":[{"name":"Chronic Care Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-2238","authenticated-orcid":false,"given":"Ali","family":"Taher","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21883"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_11_4_1","first-page":"323","article-title":"The Thalassemia Syndromes","volume":"40","author":"Weatherall D. 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