{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:11:13Z","timestamp":1790334673958,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To compare clinical characteristics, microbiology, treatment burden and outcomes between lower\u2010extremity necrotising soft tissue infections associated with diabetic foot ulcers (DFU) and lower\u2010extremity necrotising soft tissue infections not associated with DFU. We retrospectively reviewed 86 surgically treated patients at a single tertiary hospital from 2015 to 2025. Twenty patients had diabetic foot ulcer\u2013associated infections and 66 had infections from other causes. Baseline characteristics, laboratory findings, microbiology, resource utilisation, wound healing, amputation and mortality were compared between the cohorts. The diabetic foot ulcer\u2010associated group had a longer diabetes duration, higher glycated haemoglobin and a greater prevalence of hypertension, coronary heart disease and chronic kidney disease. Microbiological profiles showed overlapping distributions of major pathogens. The proportion of patients who were alive with a healed wound at 90\u2009days was lower in the DFU\u2010associated group (35.0% vs. 80.3%), and overall amputation was more frequent (55.0% vs. 15.2%), primarily driven by minor amputation (40.0% vs. 1.5%). Major amputation (15.0% vs. 13.6%) and mortality (10.0% vs. 4.5%) did not differ statistically, although estimates were imprecise. Lower\u2010extremity necrotising soft tissue infections associated with DFU were associated with greater comorbidity, resource utilisation, minor amputation and a lower proportion of patients alive with a healed wound at 90\u2009days. This retrospective study cannot determine whether minor amputation improves survival or prevents major amputation.<\/jats:p>","DOI":"10.1111\/iwj.71045","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:48:40Z","timestamp":1790326120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diabetic Foot Ulcer\u2013Associated Versus Other Lower\u2010Extremity Necrotising Soft\u2010Tissue Infections: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5532-9758","authenticated-orcid":false,"given":"Haowu","family":"Tang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Shandong Second Medical University  Weifang Shandong China"},{"name":"Department of Endocrinology and Foot &amp; Ankle Surgery, Yantai Yuhuangding Hospital Qingdao University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine Binzhou Medical University  Binzhou Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7018-104X","authenticated-orcid":false,"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Shandong Second Medical University  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0053-9006","authenticated-orcid":false,"given":"Xinzhu","family":"Song","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Shandong Second Medical University  Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Foot &amp; Ankle Surgery, Yantai Yuhuangding Hospital Qingdao University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Foot &amp; Ankle Surgery, Yantai Yuhuangding Hospital Qingdao University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Foot &amp; Ankle Surgery, Yantai Yuhuangding Hospital Qingdao University  Yantai Shandong China"},{"name":"Shandong Provincial Medicine and Health Key Laboratory of Endocrine and Metabolic Disease and Clinical Translational Medicine  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Foot &amp; Ankle Surgery, Yantai Yuhuangding Hospital Qingdao University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2024.12.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.054"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221\u20101691(12)60052\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001857"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3657"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002774"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017\u2010018\u20100219\u20109"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3687"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12040752"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2024.01.003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3648"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.18683\/germs.2023.1406"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.71045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.71045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.71045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:54:35Z","timestamp":1790333675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.71045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/iwj.71045"],"URL":"https:\/\/doi.org\/10.1111\/iwj.71045","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71045"}}