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Although numerous studies have identified factors associated with surgical site infections, synthesised and comprehensive evidence specific to weight\u2010bearing arthroplasty remains limited. This systematic review determined the epidemiological associations between intrinsic and extrinsic factors and the development of surgical site infection in adults undergoing hip, knee and\/or ankle arthroplasty, using the JBI methodology for systematic reviews of aetiology and risk, and was registered with PROSPERO (CRD42023482491). Studies were retrieved from CINAHL, Medline, Embase, Emcare, the Cochrane Library, and reference lists. English\u2010language observational studies reporting associations between one or more risk factors and surgical site infection following weight\u2010bearing joint replacement were eligible for inclusion. All included studies underwent methodological quality appraisal. Fifty\u2010seven studies met the inclusion criteria. The number of risk factors investigated varied across studies, ranging from a single factor to multiple factors, with multiple factors identified as being significantly associated with an increased risk of surgical site infections at the multivariable levels of analysis. This evidence indicates the need for comprehensive strategies to address these risk factors throughout the patient journey in arthroplasty.<\/jats:p>","DOI":"10.1111\/iwj.71047","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:04:29Z","timestamp":1790031869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Surgical Site Infections in Adults Following a Replacement of Weight\u2010Bearing Joints: A Systematic Review"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-0138","authenticated-orcid":false,"given":"Ut T.","family":"Bui","sequence":"first","affiliation":[{"name":"School of Nursing, Centre for Healthcare Transformation, Faculty of Health Queensland University of Technology  Brisbane Queensland 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