{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:52:02Z","timestamp":1791157922519,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pyoderma gangrenosum (PG) is a rare chronic neutrophilic dermatosis closely associated with immune dysregulation and characterized by painful, treatment\u2010resistant ulcers. Currently, no standardized therapeutic protocol exists; however, topical and systemic immune\u2010modulating therapies have shown positive results. In this article, we evaluate the use of polylactic acid (PLA) matrices as a treatment option, given their immunomodulatory properties and beneficial effects on complex wounds. This case series presents six patients (ages 38\u201372, five female and one male) with chronic, non\u2010healing ulcers that persisted for 6\u2009months to 3\u2009years previous to the treatment described. PLA matrices were used as the primary wound treatment, requiring a mean of 5.3 applications for healing. Wound closure was achieved in all cases within a mean time of 13.4\u2009weeks with successful outcomes in both scar quality and appearance. PLA matrices may represent a promising local treatment option for PG ulcers; however, these preliminary findings require confirmation in larger, controlled studies.<\/jats:p>","DOI":"10.1111\/iwj.71055","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:30:38Z","timestamp":1790929838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of a Synthetic Polylactic Acid Matrix for Pyoderma Gangrenosum: A Case Series"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-9762","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Ram\u00edrez\u2010Garc\u00eda\u2010Luna","sequence":"first","affiliation":[{"name":"Division of Experimental Surgery, Faculty of Medicine McGill University  Montreal Canada"},{"name":"Coordinaci\u00f3n para la Innovaci\u00f3n y Aplicaci\u00f3n de la Ciencia y la Tecnolog\u00eda Universidad Aut\u00f3noma de 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