{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:54:31Z","timestamp":1790913271009,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcers (DFUs) are a devastating complication of diabetes that markedly affects quality of life and generates significant socioeconomic and healthcare burdens. When DFUs fail to respond to standard of care (SOC), advanced therapies including Cellular, Acellular and Matrix\u2010like Products (CAMPs) are often employed. A novel composite CAMP comprising ovine forestomach matrix and high molecular weight hyaluronic acid, termed \u2018OFM\u2010HA\u2019 has been developed for the treatment of chronic wounds and evaluated in a prospective multi\u2010centre controlled trial. For this trial, 143 subjects were randomized to receive OFM\u2010HA plus SOC or SOC alone for the treatment of chronic full thickness wounds of the foot in people with diabetes meeting prespecified eligibility criteria. The primary endpoint was the proportion of wounds healed by 12\u2009weeks. Secondary endpoints included healing time, percentage area reduction, adverse events and changes in pain and quality of life. For the modified intent\u2010to\u2010treat population, 46% (31\/68) of the OFM\u2010HA plus SOC group healed by 12\u2009weeks compared to 24% (17\/72) in the SOC alone group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). Kaplan\u2013Meier analysis favoured OFM\u2010HA plus SOC over 12\u2009weeks (log\u2010rank\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). No unexpected safety\u2010related occurrences were observed. OFM\u2010HA plus SOC increased 12\u2010week closure in this selected population. Interpretation is limited by post\u2010randomization exclusions, differential withdrawal and an adjusted comparison close to the significance threshold (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.045).\n                  <\/jats:p>","DOI":"10.1111\/iwj.71056","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:17:07Z","timestamp":1790911027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Composite Ovine Forestomach Matrix and Hyaluronic Acid\n                    <scp>CAMP<\/scp>\n                    for the Treatment of Full Thickness Wounds of the Foot in People With Diabetes: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-9175","authenticated-orcid":false,"given":"David G.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Department of Surgery Keck School of Medicine of University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-6483","authenticated-orcid":false,"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-6512","authenticated-orcid":false,"given":"John C.","family":"Lantis","sequence":"additional","affiliation":[{"name":"Department of Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-8603","authenticated-orcid":false,"given":"Paul","family":"Glat","sequence":"additional","affiliation":[{"name":"Department of Surgery Drexel University School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Reyzelman","sequence":"additional","affiliation":[{"name":"Center for Clinical Research  Castro Valley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Barry University School of Podiatric Medicine  Miami Shores Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5338-3445","authenticated-orcid":false,"given":"Adam L.","family":"Isaac","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-6639","authenticated-orcid":false,"given":"Marissa J.","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  Cody Wyoming USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M.","family":"Zelen","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic Foot Ulcers: A Review","volume":"330","author":"Armstrong D. G.","year":"2023","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2025.112036","article-title":"7 Regions Foot Ulcer Costs Study Group. Estimated Costs of Treating Two Standardised Diabetes\u2010Related Foot Ulcers of Different Severity \u2010 A Comparison of 7 Global Regions","volume":"221","author":"Dhatariya K.","year":"2025","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"24","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic Foot Ulcers and Their Recurrence","volume":"376","author":"Armstrong D. G.","year":"2017","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcdhc.2024.1440209","article-title":"Emerging Technologies for the Management of Diabetic Foot Ulceration: A Review","volume":"12","author":"Sidhu A. S.","year":"2024","journal-title":"Frontiers in Clinical Diabetes and Healthcare"},{"issue":"1","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/jrms.jrms_573_24","article-title":"Microenvironment of Diabetic Foot Ulcers: Implications for Healing and Therapeutic Strategies","volume":"30","author":"Wang J.","year":"2025","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13047-020-00383-2","article-title":"Five Year Mortality and Direct Costs of Care for People With Diabetic Foot Complications Are Comparable to Cancer","volume":"13","author":"Armstrong D. G.","year":"2020","journal-title":"Journal of Foot and Ankle Research"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v4i0.21847"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109182","article-title":"Higher Rates of All\u2010Cause Mortality and Resource Utilization During Episodes\u2010Of\u2010Care for Diabetic Foot Ulceration","volume":"184","author":"Petersen B. J.","year":"2022","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"1","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/dci22-0043","article-title":"Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers","volume":"46","author":"McDermott K.","year":"2023","journal-title":"Diabetes Care"},{"issue":"2","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s40257-019-00495-x","article-title":"Diabetic Foot Ulcers: Appraising Standard of Care and Reviewing New Trends in Management","volume":"21","author":"Aldana P. C.","year":"2020","journal-title":"American Journal of Clinical Dermatology"},{"issue":"10","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1154567","article-title":"Skin Substitutes as Treatment for Chronic Wounds: Current and Future Directions","volume":"29","author":"Vecin N. M.","year":"2023","journal-title":"Frontiers in Medicine"},{"issue":"4","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2023.32.Sup4b.S1","article-title":"Best Practice for Wound Repair and Regeneration Use of Cellular, Acellular and Matrix\u2010Like Products (CAMPs)","volume":"32","author":"Wu S.","year":"2023","journal-title":"Journal of Wound Care"},{"issue":"3","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2025.34.Sup3a.S1","article-title":"Cellular, Acellular, and Matrix\u2010Like Products (CAMPs) for Soft\u2010Tissue Reconstruction in Acute Surgical and Traumatic Wounds","volume":"34","author":"Kapp D. L.","year":"2025","journal-title":"Journal of Wound Care"},{"issue":"5","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.12968\/jowc.2025.0120","article-title":"The Hidden Costs of Limiting Access: Clinical and Economic Risks of Medicare's Future Effective Cellular, Acellular and Matrix\u2010Like Products (CAMPs) Local Coverage Determination","volume":"34","author":"Tettelbach W.","year":"2025","journal-title":"Journal of Wound Care"},{"issue":"7","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.12968\/jowc.2021.30.Sup7.S5","article-title":"Observed Impact of Skin Substitutes in Lower Extremity Diabetic Ulcers: Lessons From the Medicare Database (2015\u20102018)","volume":"30","author":"Armstrong D. G.","year":"2021","journal-title":"Journal of Wound Care"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvsvi.2025.100215","article-title":"Meta\u2010Analysis of Cellular and Acellular Tissue\u2010Based Products Demonstrates Improvement of Diabetic Foot Ulcer Healing Despite Age and Wound Size","volume":"3","author":"Lu W.","year":"2025","journal-title":"JVS\u2010Vascular Insights"},{"issue":"16","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1016\/j.biomaterials.2010.02.025","article-title":"A Functional Extracellular Matrix Biomaterial Derived From Ovine Forestomach","volume":"31","author":"Lun S.","year":"2010","journal-title":"Biomaterials"},{"issue":"4","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1742-481X.2012.01106.x","article-title":"Ovine Forestomach Matrix Biomaterial Is a Broad Spectrum Inhibitor of Matrix Metalloproteinases and Neutrophil Elastase","volume":"11","author":"Negron L.","year":"2014","journal-title":"International Wound Journal"},{"issue":"27","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1016\/j.biomaterials.2011.05.040","article-title":"Quantification of In\u00a0Vitro and In\u00a0Vivo Angiogenesis Stimulated by Ovine Forestomach Matrix Biomaterial","volume":"32","author":"Irvine S. M.","year":"2011","journal-title":"Biomaterials"},{"issue":"7","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235784","article-title":"A Novel Chemotactic Factor Derived From the Extracellular Matrix Protein Decorin Recruits Mesenchymal Stromal Cells In\u00a0Vitro and In\u00a0Vivo","volume":"15","author":"Dempsey S. G.","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.ASW.0000428862.34294.d4","article-title":"Clinical Outcomes Following the Use of Ovine Forestomach Matrix (Endoform Dermal Template) to Treat Chronic Wounds","volume":"26","author":"Liden B. A.","year":"2013","journal-title":"Advances in Skin & Wound Care"},{"issue":"4","key":"e_1_2_12_23_1","first-page":"107","article-title":"Use of Ovine\u2010Based Collagen Extracellular Matrix and Gentian Violet\/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study","volume":"29","author":"Lullove E. J.","year":"2017","journal-title":"Wounds"},{"issue":"30","key":"e_1_2_12_24_1","first-page":"61","article-title":"Use of an Ovine Collagen Dressing With Intact Extracellular Matrix to Improve Wound Closure Times and Reduce Expenditures in a US Military Veteran Hospital Outpatient Wound Center","volume":"25","author":"Ferreras D. T.","year":"2017","journal-title":"Surgical Technology International"},{"issue":"11","key":"e_1_2_12_25_1","first-page":"E73","article-title":"Comparative Effectiveness of Two Collagen\u2010Containing Dressings: Oxidized Regenerated Cellulose (ORC)\/Collagen\/Silver\u2010ORC Dressing Versus Ovine Collagen Extracellular Matrix","volume":"31","author":"Griffin L.","year":"2019","journal-title":"Wounds"},{"issue":"8","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/01.ASW.0000667052.74087.d6","article-title":"Prospective Multicenter Evaluation of an Advanced Extracellular Matrix for Wound Management","volume":"33","author":"Raizman R.","year":"2020","journal-title":"Advances in Skin & Wound Care"},{"issue":"4","key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/iwj.13670","article-title":"Retrospective Real\u2010World Comparative Effectiveness of Ovine Forestomach Matrix and Collagen\/ORC in the Treatment of Diabetic Foot Ulcers","volume":"19","author":"Bosque B. A.","year":"2022","journal-title":"International Wound Journal"},{"issue":"1","key":"e_1_2_12_28_1","first-page":"40","article-title":"Use of an Advanced Extracellular Matrix Dressing in the Treatment of Acute and Chronic Wounds: A Malaysian Case Series","volume":"5","author":"Nair H.","year":"2022","journal-title":"Wounds Asia"},{"issue":"12","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","DOI":"10.1097\/GOX.0000000000006406","article-title":"Limb Salvage via Surgical Soft\u2010Tissue Reconstruction With Ovine Forestomach Matrix Grafts: A Prospective Study","volume":"12","author":"Lawlor J.","year":"2024","journal-title":"Plastic and Reconstructive Surgery. Global Open"},{"issue":"3","key":"e_1_2_12_30_1","doi-asserted-by":"crossref","DOI":"10.7547\/22-081","article-title":"Ovine Forestomach Matrix in the Surgical Management of Complex Lower\u2010Extremity Soft\u2010Tissue Defects: A Retrospective Multi\u2010Center Case Series","volume":"113","author":"Bosque B. A.","year":"2023","journal-title":"Journal of the American Podiatric Medical Association"},{"issue":"6","key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/08853282211045770","article-title":"Further Structural Characterization of Ovine Forestomach Matrix and Multi\u2010Layered Extracellular Matrix Composites for Soft Tissue Repair","volume":"36","author":"Smith M. J.","year":"2022","journal-title":"Journal of Biomaterials Applications"},{"key":"e_1_2_12_32_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1627558","article-title":"Effectiveness of Hyaluronic Acid and Its Derivatives on Diabetic Foot Ulcer: A Systematic Review and Meta\u2010Analysis","volume":"16","author":"Yao L.","year":"2025","journal-title":"Frontiers in Endocrinology"},{"issue":"1","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142273","article-title":"Development of Hyaluronic Acid\u2010Based Hydrogels for Chronic Diabetic Wound Healing: A Review","volume":"308","author":"Zhang W.","year":"2025","journal-title":"International Journal of Biological Macromolecules"},{"issue":"2","key":"e_1_2_12_34_1","first-page":"201","article-title":"Therapeutic Potential of Hyaluronic Acid in Diabetic Foot Ulcer Healing: A Systematic Review and Bibliometric Analysis","volume":"8","author":"Sinatra J.","year":"2025","journal-title":"Vascular and Endovascular Review"},{"issue":"10","key":"e_1_2_12_35_1","doi-asserted-by":"crossref","first-page":"E149","DOI":"10.1097\/ASW.0000000000000361","article-title":"A Composite Dermal Matrix Comprising Ovine Forestomach Matrix and Hyaluronic Acid in the Treatment of Chronic Wounds Secondary to Calciphylaxis: A Case Series and Literature Review","volume":"38","author":"Le L.","year":"2025","journal-title":"Advances in Skin & Wound Care"},{"issue":"3","key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.12968\/jowc.2025.0010","article-title":"Innovative Treatment of Diabetic Ulcers: Combining Chemical Debridement and Xenograft Applications: A Case Study","volume":"34","author":"Tettelbach W.","year":"2025","journal-title":"Journal of Wound Care"},{"key":"e_1_2_12_37_1","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjag129","article-title":"Early Experience With a Composite Ovine Forestomach Matrix Graft in Chronic Lower Extremity Wounds: A Multi\u2010Center Retrospective Case Series","volume":"3","author":"Geiger J. E.","year":"2026","journal-title":"Journal of Surgical Case Reports"},{"issue":"4","key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/iwj.13759","article-title":"Multi\u2010Centre Prospective Randomised Controlled Clinical Trial to Evaluate a Bioactive Split Thickness Skin Allograft vs Standard of Care in the Treatment of Diabetic Foot Ulcers","volume":"19","author":"Armstrong D. G.","year":"2022","journal-title":"International Wound Journal"},{"issue":"4","key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/iwj.13675","article-title":"A Multi\u2010Centre, Single\u2010Blinded Randomised Controlled Clinical Trial Evaluating the Effect of Resorbable Glass Fibre Matrix in the Treatment of Diabetic Foot Ulcers","volume":"19","author":"Armstrong D. G.","year":"2021","journal-title":"International Wound Journal"},{"issue":"5","key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/iwj.13715","article-title":"Use of a Purified Reconstituted Bilayer Matrix in the Management of Chronic Diabetic Foot Ulcers Improves Patient Outcomes vs Standard of Care: Results of a Prospective Randomised Controlled Multi\u2010Centre Clinical Trial","volume":"19","author":"Armstrong D. G.","year":"2022","journal-title":"International Wound Journal"},{"issue":"10","key":"e_1_2_12_41_1","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.70763","article-title":"A Borate\u2010Based Bioactive Glass Advances Wound Healing in Non\u2010Healing Wagner Grade 1 Diabetic Foot Ulcers: A Randomised Controlled Clinical Trial","volume":"22","author":"Armstrong D. G.","year":"2025","journal-title":"International Wound Journal"},{"issue":"3","key":"e_1_2_12_42_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/wrr.12901","article-title":"Assessing the Quality of Life of People With Chronic Wounds by Using the Cross\u2010Culturally Valid and Revised Wound\u2010QoL Questionnaire","volume":"29","author":"St\u00fclpnagel C. C.","year":"2021","journal-title":"Wound Repair and Regeneration"},{"issue":"9","key":"e_1_2_12_43_1","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.70029","article-title":"A Multicentre Clinical Trial Evaluating the Outcomes of Two Application Regimens of a Unique Keratin\u2010Based Graft in the Treatment of Wagner Grade One Non\u2010Healing Diabetic Foot Ulcers","volume":"21","author":"Armstrong D. G.","year":"2024","journal-title":"International Wound Journal"},{"issue":"1","key":"e_1_2_12_44_1","article-title":"Comparing the Efficacy of a Unique Advanced Bioengineered Type\u2010I Collagen\u2010Based Skin Substitute Versus an Amnion Graft With Standard of Care in the Treatment of Non\u2010Healing Diabetic Foot Ulcers: A Randomized Clinical Trial","volume":"17","author":"Armstrong D. G.","year":"2025","journal-title":"Cureus"},{"issue":"28","key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1002\/sim.4102","article-title":"Adaptive Increase in Sample Size When Interim Results Are Promising: A Practical Guide With Examples","volume":"30","author":"Mehta C. R.","year":"2011","journal-title":"Statistics in Medicine"},{"issue":"7","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S2213-8587(24)00110-4","article-title":"Causes, Prevention, and Management of Diabetes\u2010Related Foot Ulcers","volume":"12","author":"Jeffcoate W.","year":"2024","journal-title":"Lancet Diabetes and Endocrinology"},{"issue":"3","key":"e_1_2_12_47_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1089\/ten.teb.2014.0290","article-title":"To Cross\u2010Link or Not to Cross\u2010Link? Cross\u2010Linking Associated Foreign Body Response of Collagen\u2010Based Devices","volume":"21","author":"Delgado L. M.","year":"2015","journal-title":"Tissue Engineering. Part B, Reviews"},{"issue":"2","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.smim.2007.11.003","article-title":"Immune Response to Biologic Scaffold Materials","volume":"20","author":"Badylak S. F.","year":"2008","journal-title":"Seminars in Immunology"},{"issue":"4","key":"e_1_2_12_49_1","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1021\/acs.jproteome.8b00908","article-title":"Functional Insights From the Proteomic Inventory of Ovine Forestomach Matrix","volume":"18","author":"Dempsey S. G.","year":"2019","journal-title":"Journal of Proteome Research"},{"issue":"4","key":"e_1_2_12_50_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/gels11040281","article-title":"Hyaluronic Acid and Skin: Its Role in Aging and Wound\u2010Healing Processes","volume":"11","author":"Chyli\u0144ska N.","year":"2025","journal-title":"Gels"},{"issue":"3","key":"e_1_2_12_51_1","first-page":"78","article-title":"Hyaluronic Acid in Inflammation and Tissue Regeneration","volume":"28","author":"Litwiniuk M.","year":"2016","journal-title":"Wounds"},{"issue":"1","key":"e_1_2_12_52_1","article-title":"Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology. Int","volume":"2015","author":"Cyphert J. M.","year":"2015","journal-title":"Journal of Cell Biology"},{"issue":"1","key":"e_1_2_12_53_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1152\/physrev.00052.2009","article-title":"Hyaluronan as an Immune Regulator in Human Diseases","volume":"91","author":"Jiang D.","year":"2011","journal-title":"Physiological Reviews"},{"issue":"8","key":"e_1_2_12_54_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ejcb.2006.05.009","article-title":"Hyaluronan Fragments: An Information\u2010Rich System","volume":"85","author":"Stern R.","year":"2006","journal-title":"European Journal of Cell Biology"},{"issue":"2","key":"e_1_2_12_55_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12026-014-8495-2","article-title":"Tissue Integrity Signals Communicated by High\u2010Molecular Weight Hyaluronan and the Resolution of Inflammation","volume":"58","author":"Ruppert S. M.","year":"2014","journal-title":"Immunologic Research"},{"issue":"2","key":"e_1_2_12_56_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbrc.2010.10.135","article-title":"High Molecular Weight Hyaluronic Acid Inhibits IL\u20106\u2010Induced MMP Production From Human Chondrocytes by Up\u2010Regulating the ERK Inhibitor, MKP\u20101","volume":"403","author":"Hashizume M.","year":"2010","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"e_1_2_12_57_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-3-031-30300-5_9","volume-title":"Hyaluronan: Structure","author":"Wang Y.","year":"2023"},{"issue":"3","key":"e_1_2_12_58_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.carbpol.2011.03.019","article-title":"Chemical Modifications of Hyaluronic Acid for the Synthesis of Derivatives for a Broad Range of Biomedical Applications","volume":"85","author":"Schant\u00e9 C. E.","year":"2011","journal-title":"Carbohydrate Polymers"},{"issue":"3","key":"e_1_2_12_59_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/wrr.12428","article-title":"Hyaluronic Acid Dressing (Healoderm) in the Treatment of Diabetic Foot Ulcer: A Prospective, Randomized, Placebo\u2010Controlled, Single\u2010Center Study","volume":"24","author":"Lee M.","year":"2016","journal-title":"Wound Repair and Regeneration"},{"issue":"2","key":"e_1_2_12_60_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/1534734611409371","article-title":"Two\u2010Step Autologous Grafting Using HYAFF Scaffolds in Treating Difficult Diabetic Foot Ulcers: Results of a Multicenter, Randomized Controlled Clinical Trial With Long\u2010Term Follow\u2010Up","volume":"10","author":"Uccioli L.","year":"2011","journal-title":"International Journal of Lower Extremity Wounds"},{"issue":"10","key":"e_1_2_12_61_1","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.2337\/diacare.26.10.2853","article-title":"HYAFF 11\u2010Based Autologous Dermal and Epidermal Grafts in the Treatment of Noninfected Diabetic Plantar and Dorsal Foot Ulcers: A Prospective, Multicenter, Controlled, Randomized Clinical Trial","volume":"26","author":"Caravaggi C.","year":"2003","journal-title":"Diabetes Care"},{"issue":"3","key":"e_1_2_12_62_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/1534734609344140","article-title":"Effectiveness and Safety of a Novel Gel Dressing in the Management of Neuropathic Leg Ulcers in Diabetic Patients: A Prospective Double\u2010Blind Randomized Trial","volume":"8","author":"Abbruzzese L.","year":"2009","journal-title":"International Journal of Lower Extremity Wounds"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/152091504773731357"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12509"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"e_1_2_12_66_1","unstructured":"International Working Group on the Diabetic Foot European Society for Vascular Surgery Society for Vascular Surgery \u201cIntersocietal Guideline on Peripheral Artery Disease in People With Diabetes and a Foot Ulcer \u201d(2023) https:\/\/iwgdfguidelines.org\/wp\u2010content\/uploads\/2023\/07\/IWGDF\u20102023\u201005\u2010PAD\u2010Guideline.pdf."},{"key":"e_1_2_12_67_1","unstructured":"International Working Group on the Diabetic Foot \u201cGuidelines on Interventions to Enhance Healing of Foot Ulcers in People With Diabetes \u201d(2023) https:\/\/iwgdfguidelines.org\/wp\u2010content\/uploads\/2023\/07\/IWGDF\u20102023\u201007\u2010Wound\u2010Healing\u2010Guideline.pdf."}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.71056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.71056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.71056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:17:18Z","timestamp":1790911038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.71056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/iwj.71056"],"URL":"https:\/\/doi.org\/10.1111\/iwj.71056","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71056"}}