{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:51:06Z","timestamp":1791175866066,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hyperbaric oxygen therapy (HBOT) is an adjunctive treatment for selected chronic wounds with microcirculatory impairment, but treatment response is typically assessed clinically after several weeks. This case series evaluated the feasibility and potential utility of laser speckle contrast imaging (LSCI) for monitoring cutaneous perfusion during HBOT. Six patients with chronic wounds refractory to conventional management underwent HBOT. Cutaneous perfusion was assessed using LSCI before and after HBOT sessions at three predefined regions of interest: referent healthy skin, wound margin and wound bed. Perfusion was quantified in laser speckle perfusion units (LSPUs). Baseline perfusion differed significantly among anatomical regions (Friedman test,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Median perfusion was highest at the wound margin (109 [70\u2013172] LSPU), compared with the wound bed (58 [32\u201392] LSPU;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and referent healthy skin (45 [36\u201361] LSPU;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Across monitored HBOT sessions, perfusion increased significantly after treatment in referent skin (+11 [\u22122 to +18] LSPU;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022), at the wound margin (+30 [\u22122 to +64] LSPU;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and in the wound bed (+10 [+1 to +32] LSPU;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010). Pre\u2010HBOT wound\u2010bed perfusion tended to decrease over the treatment course in most patients, although substantial inter\u2010individual variability was observed. This case series demonstrates the feasibility of repeated, non\u2010invasive LSCI assessment to characterize spatial and acute changes in cutaneous microcirculatory perfusion during HBOT. LSCI appears feasible for monitoring cutaneous perfusion during HBOT. Prospective studies with standardized assessment time points are needed to determine whether LSCI\u2010derived perfusion trajectories or thresholds are associated with wound\u2010healing outcomes and can inform HBOT decision\u2010making.\n                  <\/jats:p>","DOI":"10.1111\/iwj.71075","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:52:05Z","timestamp":1791165125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laser Speckle Contrast Imaging for Assessment of Cutaneous Perfusion and Treatment Response During Hyperbaric Oxygen Therapy in Chronic Wounds: A Case Series"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-1777","authenticated-orcid":false,"given":"Stanislas","family":"Abrard","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Hospices Civils de Lyon, Edouard Herriot Hospital  Lyon France"},{"name":"Research on Healthcare Performance RESHAPE, INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Facult\u00e9 de M\u00e9decine Lyon Est Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Brenac","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon H\u00f4pital Croix Rousse, Service de Chirurgie Plastique, Esth\u00e9tique et R\u00e9paratrice  Lyon France"},{"name":"Hospices Civils de Lyon H\u00f4pital Edouard\u2010Herriot, Centre de Traitement Des br\u00fbl\u00e9s Pierre\u2010Colson  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landry","family":"Jacquet","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine Hyperbare H\u00f4pital \u00c9douard\u2010Herriot  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-6827","authenticated-orcid":false,"given":"Judith","family":"Catella","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Vasculaire H\u00f4pital Edouard Herriot, Hospices Civils de Lyon  Lyon France"},{"name":"UMR 5305: Laboratoire de Biologie Tissulaire et Ing\u00e9nierie Th\u00e9rapeutique CNRS\/Universit\u00e9 Claude Bernard Lyon 1, Institut de Biologie et Chimie des Prot\u00e9ines  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Joffre","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine Hyperbare H\u00f4pital \u00c9douard\u2010Herriot  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2025.06.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090864"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.92728"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICEENG45378.2020.9171697"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200\u2010021\u201000891\u20103"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12776"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12819"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0268355517718760"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000715\u20101"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2017.06.010"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106579\/ab2058"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.06.018"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2017.986"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11082\u2010022\u201003658\u2010z"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102190"}],"container-title":["International 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