{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:44:11Z","timestamp":1792629851076,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To describe recorded outcomes of diabetic foot ulcers treated with topical recombinant human epidermal growth factor as part of routine care. This retrospective, single\u2010centre cohort study included 150 consecutive patients receiving Regen\u2010D 150 without a control group. We added treatment when standard care did not produce adequate granulation. We defined the primary outcome as complete healing of the index ulcer without amputation. The primary outcome occurred in 101\/150 patients (67.3%; 95% confidence interval 59.5\u201374.3). Sixteen underwent amputation (11 minor, 5 major), 27 had ongoing status at last follow\u2010up, three died and three were lost to follow\u2010up. Ongoing status included open wounds and closed but unconfirmed wounds. Median recorded time to healing was 13\u2009weeks (interquartile range 10\u201316). Wound area analyses were exploratory because of unresolved timing inconsistencies. We could not confirm healing for all recorded healings. About two\u2010thirds had recorded healing without amputation during variable follow\u2010up. These uncontrolled, descriptive findings do not establish efficacy, superiority or amputation prevention.<\/jats:p>","DOI":"10.1111\/iwj.71076","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:29:37Z","timestamp":1792625377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Topical Recombinant Human Epidermal Growth Factor in Diabetic Foot Ulcers: A Retrospective Single\u2010Centre Cohort Study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-7467","authenticated-orcid":false,"given":"Haci Vural","family":"Soyer","sequence":"first","affiliation":[{"name":"Department of General Surgery, Chronic Wound Unit Mersin City Training and Research Hospital  Mersin 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